>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
哮喘和抑郁共病的潜在机制
作者:Ashok Thapa1  张钰群2  袁勇贵1 
单位:1. 东南大学附属中大医院 心理精神科, 江苏 南京 210009;
2. 南京中医药大学 护理学院, 江苏 南京 210023
关键词:哮喘 抑郁 共病 机制 综述 
分类号:R562.25;R749.4
出版年·卷·期(页码):2020·39·第五期(655-660)
摘要:

哮喘是一种常见的心身疾病,哮喘患者抑郁的发生率较高。既往研究表明抑郁的存在能够诱发和加重哮喘症状,降低患者的生活质量。哮喘和抑郁的高共患率提示它们之间可能存在某些共同的发病机制。因此,作者分别从免疫、内分泌、神经生化、遗传学、神经影像和心理因素等方面对哮喘和抑郁进行了综述,拟寻找两者共同的发病机制,从而为临床诊治提供更多的理论依据。

参考文献:

[1] BOULET L P,BOULAY M E.Asthma-related comorbidities[J].Expert Rev Respir Med,2011,5:377-393.
[2] STACHLER R J.Comorbidities of asthma and the unified airway[J].Int Forum Allergy Rhinol,2015,5:S17-22.
[3] BATEMAN E D,HURD S S,BARNES P J,et al.Global strategy for asthma management and prevention:GINA executive summary[J].Eur Respir J,2008,31(1):143-178.
[4] WANG H,NAGHAVI M,ALLEN C,et al.GBD 2015 mortality and causes of death,collaborators.Global,regional,and national life expectancy,all-cause mortality,and cause-specific mortality for 249 causes of death,1980-2015:a systematic analysis for the global burden of disease study 2015[J].Lancet,2016,388(10053):1459-1544.
[5] TO T,STANOJEVIC S,MOORES G,et al.Global asthma prevalence in adults:findings from the cross-sectional world health survey[J].BMC Public Health,2012,12:204.
[6] MASOLI M,FABIAN D,HOLT S,et al.The global burden of asthma:executive summary of the GINA dissemination committee report[J].Allergy,2004,59:469-478.
[7] DOZ M,CHOUAID C,COM-RUELLE L,et al.The association between asthma control,health care costs,and quality of life in France and Spain[J].BMC Pulm Med,2013,13:15.
[8] BOULET L P.Influence of comorbid conditions on asthma[J].Eur Respir J,2009,33:897-906.
[9] SU X,REN Y,LI M,et al.Prevalence of comorbidities in asthma and nonasthma patients:a Meta-analysis[J].Medicine,2016,95(22):e3459.
[10] LIU S,WU R,LI L,et al.The prevalence of anxiety and depression in Chinese asthma patients[J].PLoS One,2014,9(7):e103014.
[11] LU Y,HO R,LIM T K,et al.Psychiatric comorbidities in Asian adolescent asthma patients and the contributions of neuroticism and perceived stress[J].J Adolesc Health,2014,55(2):267-275.
[12] CIPRANDI G,SCHIAVETTI I,RINDONE E,et al.The impact of anxiety and depression on outpatients with asthma[J].Ann Allergy Asthma Immunol,2015,115(5):408-414.
[13] LU Y,MAK K K,VAN BEVER H P,et al.Prevalence of anxiety and depressive symptoms in adolescents with asthma:a meta-analysis and meta-regression[J].Pediatr Allergy Immunol,2012,23(8):707-715.
[14] SHEN T C,LIN C L,LIAO C H,et al.Major depressive disorder is associated with subsequent adult-onset asthma:a population-based cohort study[J].Epidemiol Psychiatr Sci,2017,26(6):664-671.
[15] CHEN E,MILLER G E.Stress and inflammation in exacerbations of asthma[J].Brain Behav Immun,2007,21(8):993-999.
[16] CHUNG J H,KIM S H,LEE Y W.Suicidal ideation and suicide attempts among asthma[J].Ann Gen Psychiatry,2016,15:35.
[17] WOUTERS E F,REYNAERT N L,DENTENER M A,et al.Systemic and local inflammation in asthma and chronic obstructive pulmonary disease:is there a connection?[J].Proc Am Thorac Soc,2009,6:638-647.
[18] SHARMA S,SHARMA A,KUMAR S,et al.Association of TNF haplotypes with asthma,serum IgE levels,and correlation with serum TNF-alpha levels[J].Am J Respir Cell Mol Biol,2006,35:488-495.
[19] HIGASHIMOTO Y,YAMAGATA Y,TAYA S,et al.Systemic inflammation in chronic obstructive pulmonary disease and asthma:similarities and differences[J].Respirology,2008,13:128-133.
[20] HALVANI A,TAHGHIGHI F,NADOOSHAN H H.Evaluation of correlation between airway and serum inflammatory markers in asthmatic patients[J].Lung India,2012,29:143-146.
[21] MAES M.A review on the acute phase response in major depression[J].Rev Neurosci,1993,4(4):407-416.
[22] LEONARD B E.Pain,depression and inflammation:are interconnected causative factors involved?[J].Mod Trends Pharmacopsychiatry,2015,30:22-35.
[23] YOUNG J J,BRUNO D,POMARA N.A review of the relationship between proinflammatory cytokines and major depressive disorder[J].J Affect Disord,2014,169:15-20.
[24] LEVINE J,BARAK Y,CHENGAPPA K N,et al.Cerebrospinal cytokine levels in patients with acute depression[J].Neuropsychobiology,1999,40(4):171-176.
[25] RAISON C L,BORISOV A S,MAJER M,et al.Activation of central nervous system inflammatory pathways by interferon-alpha:relationship to monoamines and depression[J].Biol Psychiatry,2009,65(4):296-303.
[26] VALKANOVA V,EBMEIER K P,ALLAN C L.CRP,IL-6 and depression:a systematic review and meta-analysis of longitudinal studies[J].J Affect Disord,2013,150(3):736-744.
[27] JIANG M,QIN P,YANG X.Comorbidity between depression and asthma via immune inflammatory pathways:a meta-analysis[J].J Affect Disord,2014,166:22-29.
[28] ESPINOSA LEAL F D,PARRA ROMAN M,MENDEZ N H,et al.Anxiety and depression in asthmatic adults in comparison to healthy individuals[J].Rev Alerg Mex,2006,53:201-206.
[29] DI MARCO F,SANTUS P,CENTANNI S.Anxiety and depression in asthma[J].Curr Opin Pulm Med,2011,17:39-44.
[30] SHARMA S,SHARMA A,KUMAR S,et al.Association of TNF haplotypes with asthma,serum IgE levels,and correlation with serum TNF-alpha levels[J].Am J Respir Cell Mol Biol,2006,35:488-495.
[31] VAN LIESHOUT R J,MACQUEEN G.Psychological factors in asthma[J].Allergy Asthma Clin Immunol,2008,4:12-28.
[32] PRIFTIS K N,PAPADIMITRIOU A,NICOLAIDOU P,et al.Testing for hypothalamic-pituitary-adrenal axis suppression in asthmatic children[J].Pediatr Allergy Immunol,2008,19:466-467.
[33] RINGDAL N,LUNDBACK B,ALTON M,et al.Comparable effects of inhaled fluticasone propionate and budesonide on the HPA-axis in adult asthmatic patients[J].Respir Med,2000,94:482-489.
[34] RUSSO S J,NESTLER E J.The brain reward circuitry in mood disorders[J].Nat Rev Neurosci,2013,14:609-625.
[35] VILLANUEVA R.Neurobiology of major depressive disorder[J].Neural Plast,2013,2013:873278.
[36] FISCHER A,MCGREGOR G P,SARIA A,et al.Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation[J].J Clin Invest,1996,98:2284-2291.
[37] SAID S I.Influence of neuropeptides on airway smooth muscle[J].Am Rev Respir Dis,1987,136:52-58.
[38] DEY R D,SHIMOSEGAWA T,SAID S I.Lung peptides and the pulmonary circulation[M].//Said SIt.The pulmonary circulation and acute lung injury.2nd ed.NY:Futura Publishing Co Inc,1991:137-175.
[39] RICHARDSON J,BELAND J.Nonadrenergic inhibitory nervous system in human airways[J].J Appl Physiol,1976,41:764-771.
[40] MATSUZALD Y,HAMASAKI Y,SAID S I.Vasoactive intestinal peptide:a possible transmitter of nonadrenergic relaxation of guinea pig airways[J].Science,1980,210(4475):1252-1253.
[41] NICOLL R A,SCHENKER C,LEEMAN S.Substance P as a transmitter candidate[J].Ann Rev Neurosci,1980,3:227-268.
[42] DEY R D,MITCHELL H,COBURN R F.Organization and development of peptide-containing neurons in the airways[J].Am J Respir Cell Mol Bioi,1990,3:187-188.
[43] BARNES P J.Neuropeptides and asthma[J].Am Rev Respir Dis,1991,143(3 Pt 2):S28-32.
[44] JOACHIM R A,SAGACH V,QUARCOO D,et al.Neurokinin-1 receptor mediates stress-exacerbated allergic airway inflammation and airway hyperresponsiveness in mice[J].Psychosom Med,2004,66:564-571.
[45] HOKFELT T,BROBERGER C,XU Z Q,et al.Neuropeptides-an overview[J].Neuropharmacology,2000,39:1337-1356.
[46] GERSHON D.Cell signalling:making connections[J].Nature,2004,432:243-249.
[47] MATKAR N M,RUPWATE R U,DESAI N K,et al.Comparative study of platelet histamine and serotonin with their corresponding plasma oxidases in asthmatics with normal[J].J Assoc Physicians India,1999,47:878-882.
[48] DUFFY D L,MARTIN N G,BATTISTUTTA D,et al.Genetics of asthma and hay fever in Australian twins[J].Am Rev Respir Dis,1990,142(6 Pt 1):1351-1358.
[49] DAVIS J B.Neurotic illness in the families of children with asthma and wheezy bronchitis:a general practice population study[J].Psychol Med,1977,7:305-310.
[50] WAMBOLDT M Z,WEINTRAUB P,KRAFCHICK D,et al.Psychiatric family history in adolescents with severe asthma[J].J Am Acad Child Adolesc Psychiatry,1996,35:1042-1049.
[51] BROWN E S,GAN V,JEFFRESS J.Psychiatric symptomatology and disorders in caregivers of children with asthma[J].Pediatrics,2006,118:e1715-e1720.
[52] ORTEGA A N,GOODWIN R D,MCQUAID E L,et al.Parental mental health,childhood psychiatric disorders,and asthma attacks in island Puerto Rican youth[J].Ambul Pediatr,2004,4:308-315.
[53] WAMBOLDT M Z,HEWITT J K,SCHMITZ S.Familial association between allergic disorders and depression in adult Finnish twins[J].Am J Med Genet,2000,96:146-153.
[54] WATANABE T,FAJT M L,TRUDEAU J B,et al.Brain derived neurotrophic factor (BDNF) expression in asthma.Association with severity and type-2 inflammatory processes[J].Am J Respir Cell Mol Biol,2015,53(6):844-852.
[55] OZEK E,EKICI B.Asthma and suicide:possible role of brainderived neurotrophic factor[J].Med Hypotheses,2011,77:261-262.
[56] TSAI S J.Major depression and brain-derived neurotrophic factor[J].Med Hypotheses,2005,65:417-418.
[57] ANDIAPPAN A K,PARATE P N,ANANTHARAMAN R,et al.Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore[J].Cytokine,2011,56:218-223.
[58] DONNER J,HAAPAKOSKI R,EZER S,et al.Assessment of the neuropeptide S system in anxiety disorders[J].Biol Psychiatry,2010,68(5):474-483.
[59] RISCH N,HERRELL R,LEHNER T,et al.Interaction between the serotonin transporter gene (5-HTTLPR),stressful life events,and risk of depression:a meta-analysis[J].JAMA,2009,301(23):2462-2471.
[60] OMARI-ASOR L,STEWART R,ARTERO S,et al.5-HTTLPR genotype,asthma,diabetes and late-life depression in an older French population[J].Int J Geriatr Psychiatry,2015,30:1017-1022.
[61] YANG Y,ZHAO M,ZHANG Y,et al.Correlation of 5-HTT,BDNF and NPSR1 gene polymorphisms with anxiety and depression in asthmatic patients[J].Int J Mol Med,2016,38(1):65-74.
[62] ROSENKRANZ M A,BUSSE W W,JOHNSTONE T,et al.Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation neural circuitry underlying the interaction between emotion and asthma symptom exacerbation[J].Proc Natl Acad Sci U S A,2005,102(37):13319-13324.
[63] ROSENKRANZ M A,BUSSE W W,SHERIDAN J F,et al.Are there neurophenotypes for asthma?Functional brain imaging of the interaction between emotion and inflammation in asthma[J].PLoS One,2012,7(8):e40921.
[64] ROSENKRANZ M A,DAVIDSON R J.Affective neural circuitry and mind-body influences in asthma[J].Neuroimage,2009,47(3):972-980.
[65] KLINE J N,ROSE R M.Central nervous system influences in asthma[J].Adv Exp Med Biol,2014,795:309-319.
[66] BORSOOK D,VEGGEBERG R,ERPELDING N,et al.The insula:a "hub of activity" in migraine[J].Neuroscientist,2016,22(6):632-652.
[67] LIOTTI M,BRANNAN S,EGAN G,et al.Brain responses associated with consciousness of breathlessness (air hunger)[J].Proc Natl Acad Sci U S A,2001,98(4):2035-2040.
[68] NIEUWENHUYS R.The insular cortex:a review[J].Prog Brain Res,2012,195:123-163.
[69] XIONG X,ZHU H,WANG T,et al.Altered intrinsic regional brain activity in female asthmatics with or without depressive symptoms:a resting-state functional magnetic resonance imaging study[J].J Asthma,2016,53(9):922-929.
[70] ZHANG Y,YANG Y,BIAN R,et al.Abnormal functional connectivity of ventral anterior insula in asthmatic patients with depression[J].Neural Plast,2017,2017:7838035.
[71] WANG L,WANG T,LIU S,et al.Cerebral anatomical changes in female asthma patients with and without depression compared to healthy controls and patients with depression[J].J Asthma,2014,51(9):927-933.
[72] SANDBERG S,PATON J Y,AHOLA S,et al.The role of acute and chronic stress in asthma attacks in children[J].Lancet,2000,356(9234):982-987.
[73] TRUEBA A F,RITZ T.Stress,asthma,and respiratory infections:pathways involving airway immunology and microbial endocrinology[J].Brain Behav Immun,2013,29:11-27.
[74] VON LEUPOLDT A,EHNES F,DAHME B.Emotion and respiratory function in asthma:a comparision of findings in everyday life and laboratory[J].Br J Health Psychol,2006,11(Pt 2):185-198.
[75] KLINNERT M D,NELSON H S,PRICE M R,et al.Onset and persistence of childhood asthma:predictors form infancy[J].Pediatrics,2001,108(4):E69.
[76] JOHNSON S L,CUELLAR A K,GERSHON A.The influence of trauma,life events,and social relationships on bipolar depression[J].Psychiatr Clin North Am,2015,39(1):87-94.
[77] CHIDA Y,HAMER M,STEPTOE A.A bidirectional relationship between psychosocial factors and atopic disorders:a systematic review and meta-analysis[J].Psychosom Med,2008,70(1):102-116.
[78] JUNIPER E F.Effect of asthma on quality of life[J].Can Respir J,1998,5(Suppl A):77A-84A.
[79] SANDER J B,MCCARTY C A.Youth depression in the family context:familial risk factors and models of treatment[J].Clin Child Fam Psychol Rev,2005,8(3):203-219.
[80] NETO F L,BORGES G,TORRES-SANCHEZ S,et al.Neurotrophins role in depression neurobiology:a review of basic and clinical evidence[J].Curr Neuropharmacol,2011,9(4):530-552.
[81] MOUSSAVI S,CHATTERJI S,VERDES E,et al.Depression,chronic diseases,and decrements in health:results from the World Health Surveys[J].Lancet,2007,370(9590):851-858.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 412642 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364