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ctDNA在可切除结直肠癌肝转移中的应用
作者:王真  刘燕文 
单位:东南大学 医学院, 江苏 南京 210009
关键词:循环肿瘤DNA 结直肠癌肝转移 手术评估 无疾病状态 复发转移 综述 
分类号:R735.3
出版年·卷·期(页码):2020·39·第四期(509-513)
摘要:

肝脏是结直肠癌最易转移部位,结直肠癌肝转移手术切除是延长生存期的重要方式之一。但是目前关于术前评估和术后监测的手段有限,不能指导精准治疗。液体活检具有实时动态监测的优势,在肿瘤精准治疗中有巨大应用前景。其中循环肿瘤DNA(ctDNA)有望在结直肠癌肝转移手术中成为一个合适的生物活检标志物。作者详细阐述了ctDNA与组织活检相关性的研究进展、ctDNA在筛选适合手术的结直肠癌肝转移患者中的作用、ctDNA对术后切除状态的评估以及在术后监测中的作用。

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