心肌肥厚是心脏为适应各种刺激所产生的心肌细胞体积增大和间质增生，最终可导致心力衰竭甚至死亡。在探究其发病机制的过程中发现，错误折叠蛋白的产生和堆积可导致肥厚性心肌病。泛素化蛋白酶系统（UPS）是蛋白质质量控制的核心。泛素化过程需要由E1泛素激活酶、E2泛素缀合酶和E3泛素连接酶协同作用完成。三联基序（TRIM）蛋白属于E3泛素化连接酶家族，在心肌肥厚的蛋白质质量控制中发挥重要作用。本文作者综述了TRIM家族在病理性心肌肥厚发展过程中的作用以及相关的信号通路和分子机制，以期为心肌肥厚的临床治疗提供新的思路。

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