目的：评估多种外周血炎症标志物与克罗恩病（CD）内镜活动性的关系以及在CD诊断中的临床价值。方法：对2015年1月至2019年12月就诊于东南大学附属中大医院的102例CD患者（包括CD活动组53例和CD缓解组49例）以及42例肠易激综合征患者（对照组）进行回顾性分析。比较各组中性粒细胞（N）、淋巴细胞（L）、单核细胞（M）和血小板（PLT）及其比值的变化，并分析各指标与CD简化内镜评分（SES-CD）、C-反应蛋白（CRP）、红细胞沉降率（ESR）之间的相关性。采用受试者工作特征（ROC）曲线分析相关炎症标志物在鉴别疾病状态中的诊断能力。结果：与对照组比较，CD缓解组L水平显著降低，而单核细胞/淋巴细胞值（MLR）和血小板/淋巴细胞值（PLR）水平均显著升高（均P<0.05）。与CD活动组相比，CD缓解组中的N、M、PLT、中性粒细胞/淋巴细胞值（NLR）、MLR和PLR水平均显著降低（均P<0.05）。Spearman相关分析显示，CD活动组和CD缓解组中的MLR水平均与SES-CD评分和CRP水平呈正相关（均P<0.05）。ROC曲线分析表明，MLR在CD缓解组与对照组及CD活动组的鉴别诊断中均显示出最高的诊断效能。Logistic回归分析显示，MLR是判断CD内镜活动性的独立相关因素（β=6.788，P=0.008）。结论：MLR与CD内镜活动性之间具有较好的相关性，可间接反映CD的疾病活动状态，同时在CD的鉴别诊断中也具有重要的意义。

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