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艰难梭菌感染实验室诊断方法的研究进展
作者:吴伶俐1  李楣2 
单位:1. 东南大学附属中大医院 检验中心, 江苏 南京 210009;
2. 重庆市第十三人民医院 检验科, 重庆 400053
关键词:艰难梭菌 毒素 检测 综述 
分类号:R378.8;R446.5
出版年·卷·期(页码):2020·39·第三期(403-406)
摘要:

艰难梭菌是存在于人体肠道中的一种专性厌氧革兰阳性芽孢杆菌,系条件致病菌,可引起从轻微腹泻到致命的伪膜性结肠炎等轻重不等的临床症状。艰难梭菌感染(Clostridioides difficile infection, CDI)的发病率和死亡率在全球范围内不断增高,特别是北美地区027型高产毒力菌株造成的医院内暴发流行,引起了世界范围的广泛关注。CDI的诊断主要依据临床表现和实验室检查,在缺乏患者相应的临床症状时,CDI实验室诊断显得尤为重要。本文作者从艰难梭菌的厌氧培养、免疫分析和核酸扩增等实验室诊断方法的研究进展进行综述,为CDI的早期诊断和治疗提供新思路。

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