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肿瘤转移分子机制与治疗成像的研究进展
作者:陈怡文  姜添铖  杨雯迪  陈泽欣  张建琼 
单位:东南大学医学院"发育与疾病相关基因"教育部重点实验室, 江苏 南京 210009
关键词:肿瘤转移 靶向治疗 分子成像 微环境 综述 
分类号:R73-37
出版年·卷·期(页码):2020·39·第三期(365-370)
摘要:

肿瘤是危害人体健康的世界性问题之一,而肿瘤的转移是其发生发展过程中最具危险性的阶段,也是造成患者死亡的首要原因。随着对肿瘤转移机制的深入研究,针对肿瘤转移的治疗思路从非特异性治疗发展到特异性靶向治疗,同时对肿瘤微环境中动态变化所出现的特异性靶点的研究也推动了分子成像的进步。本文作者就肿瘤转移的分子机制及靶点、治疗策略和分子成像进行综述。

参考文献:

[1] 刘洋,曹雪涛.肿瘤转移前微环境的特征与作用[J].中国肿瘤生物治疗杂志,2017,24(10):1148-1150.
[2] YANG J, LU C J, WEI J C, et al.Abstract 1526: KPNA4 promotes prostate cancer metastasis through TNFΑ/Β mediated cytokine crosstalk in tumor microenvironment[J].Cancer Res,2016,76(14 Supplement):1526.
[3] LISANTI M P, MARTINEZ-OUTSCHOORN U E, LIN Z, et al.Hydrogen peroxide fuels aging,inflammation,cancer metabolism and metastasis: the seed and soil also needs "fertilizer"[J].Cell Cycle,2011,10(15):2440-2449.
[4] 陈惠,渠景连,龚婕宁.现代医学对恶性肿瘤转移相关机制的研究进展[J].中国中药杂志,2014,39(15):2823-2828.
[5] POSTE G, FIDLER I J. The pathogenesis of cancer metastasis[J].Nature,1980,283(5743):139-146.
[6] 杨壹羚,褚嘉祐,王明荣.肿瘤遗传异质性[J].遗传,2013,35(1):1-9.
[7] GUPTA P G, MASSAGUE J. Cancer metastasis: building a framework[J].Cell,2006,127(4):679-695.
[8] JOYCE J A, POLLARD J W. Microenvironmental regulation of metastasis[J].Nat Rev Cancer, 2009, 9(4):239-252.
[9] NDIAYE P D, PAGōS G.[VEGF-C and lymphatic vessels:a double-edged sword in tumor development and metastasis][J].Med Sci (Paris), 2019,35(2):132-137.
[10] PAEZ-RIBES M, ALLEN E, HUDOCK J, et al.Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis[J].2009, Cancer Cell, 15(3):220-231.
[11] LI J, WANG W, SHENG S, et al.FOXA1 reprograms the TGF-β-stimulated transcriptional program from a metastasis promoter to a tumor suppressor in nasopharyngeal carcinoma[J].Cancer Lett,2019,442:1-14.
[12] MA F, LI W J, LIU C X, et al.MiR-23a promotes TGF-β1-induced EMT and tumor metastasis in breast cancer cells by directly targeting CDH1 and activating Wnt/β-catenin signaling[J].Oncotarget,2017,8(41):69538-69550.
[13] GUO X B, HUANG B, PAN Y H, et al.ESCO2 inhibits tumor metastasis via transcriptionally repressing MMP2 in colorectal cancer[J].Cancer Manag Res,2018,10:6157-6166.
[14] FANG J H, ZHOU H C, ZHENG C X, et al.MicroRNA-29b suppresses tumor angiogenesis, invasion and metastasis by regulating MMP-2 expression[J].Hepatology,2011,54(5):1729-1740.
[15] WANG X F, NAGASE H, WATANABE T,et al.Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide[J].Cancer Sci,2010,101(3):759-766.
[16] LI S, LI Q. Cancer stem cells and tumor metastasis (Review)[J].Int J oncol,2014,44(6):1806-1812.
[17] BAO S D, WU Q L, SATHORNSUMETEE S, et al.N. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor[J].Cancer Res,2006,66(16):7843-7848.
[18] WAKAMATSU Y, SAKAMOTO N, NAITO Y, et al.Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer[J].Pathol Int,2012,62(2):112-119.
[19] OKUYAMA K, FUKUSHIMA H, NARUSE T,et al.CD44 variant 6 expression and tumor budding in the medullary invasion front of mandibular gingival squamous cell carcinoma are predictive factors for cervical lymph node metastasis[J].Pathol Oncol Res,2019,25(2):603-609.
[20] CHEN C H, SHIU L Y, SU L J, et al.FLJ10540 is associated with tumor progression in nasopharyngeal carcinomas and contributes to nasopharyngeal cell proliferation and metastasis via the osteopontin/CD44 pathway[J].J Transl Med,2012,10(1):93.
[21] TIAN L, DUAN Y J, NIE L Z, et al.[The regulation of CD44 expression by new tumor suppressor gene Arid2 and the influence of Arid2 on the invasion and metastasis in hepatocellular carcinoma cells][J].Chin J Hepatol,2016,24(3):196-201.
[22] KAZAMA S, KISHIKAWA J, YASUDA K, et al.CD133 expression in lymph node metastases is associated with tumor aggressiveness during lymph node metastasis in colorectal cancer[J].Anticancer Res,2015,35(12):6599-6605.
[23] KALLURI R, WEINBERG R A. The basics of epithelial-mesenchymal transition[J].J Clin Invest,2009,119(6):1420-1428.
[24] WAKAMATSU Y, SAKAMOTO N, OO H,et al.Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer[J].Pathol Int,2012,62(2):112-119.
[25] THOMAS A, JUNG A, SPADERNA S, et al.Migrating cancer stem cells-an integrated concept of malignant tumor progression[J].Nat Rev Cancer,2005,5(9):744-749.
[26] HOU Y, ZOU Q F, GE R L, et al.The critical role of CD133(+) CD44(+/high) tumor cells in hematogenous metastasis of liver cancers[J].Cell Res,2011,22(1):259-272.
[27] DAS V, BHATTACHARYA S,CHIKKAPUTTAIAH C. The basics of epithelial-mesenchymal transition (EMT):A study from a structure, dynamics, and functional perspective[J].J Cell Physiol,2019,234(2):1-21.
[28] BURK U, SCHUBERT J, WELLNER U, et al.A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells[J].EMBO Rep,2008,9(6):582-589.
[29] YANG J, MANI S A, DONAHER J L, et al.Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis[J].Cell,2004,117(7):927-939.
[30] YANG X J, ZHANG Y, KAYOKO,et al.VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients[J].Proc Natl Acad Sci,2015,112(22):2900-2909.
[31] ALLISON S. Epigenetic silencing of mIR-125b-1 regulates PIGF expression and contributes to tumor anglogenesis and Invasion in human hepatocellular carcinoma[C]//Abstracts of 21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology.中国生物化学与分子生物学会,2009:1.
[32] 王杰军,应明真.恶性肿瘤的转移机制与治疗策略[J].中国肿瘤生物治疗杂志,2008,15(4):305-310.
[33] SINKEVICIUS K W, BELLARIA K J, BARRIOS J, et al.E-cadherin Loss Accelerates Tumor Progression and Metastasis in a Mouse Model of Lung Adenocarcinoma[J].Am J Respir Cell and Mol Biol,2018,59(2):237-245.
[34] MILLER A B, HOOGSTRATEN B, STAQUET M, et al.Reporting results of cancer treatment[J].Cancer, 1981,47(1):207-214.
[35] SCHIFF P B, FANT J, HORAITE S B. Promotion of microtubule assemble in vitro by taxol[J].Nature,1979(277):665-666.
[36] AMIRI M M, BAHADORI T, SOLTANTOYEH T. Development of a novel inhibitory chimeric anti-HER2 monoclonal antibody[J].Iran J Immunol, 2019,16(1):26-42.
[37] NIK M E, MOMTAZI-BOROJWNI A A, ZAMANI P, et al.Targeted-nanoliposomal combretastatin A4 (CA-4) as an efficient antivascular candidate in the metastatic cancer treatment[J].J Cell Physiol, 2019,234(9):14721-14733.
[38] GOEL S, DUDA D G, XU L, et al.Normalization of the vasculature for treatment of cancer and other diseases[J].Physiol Rev, 2011, 91(3):1071-1121.
[39] CAI W, CHEN K, MOHAMEDALI K A, et al.PET of vascular endothelial growth factor receptor expression[J].J Nucl Med, 2006, 47(12):2048-2056.
[40] DOSSI R, FRAPOLLI R, SILVANA DI G, et al.Antiangiogenic activity of trabectedin in myxoid liposarcoma: involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1[J].Int J Cancer, 2015, 136(3):721-729.
[41] REYA T, MORRISON S J, CLARKE M F et al.Stem cells, cancer, and cancer stem cells[J].Nature, 2001,414(6859):105-111.
[42] KIM W K, BYUN W S, CHUNG H J, et al.Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer[J].Biochem Pharmacol,2018,152:71-83.
[43] NOORI J, SHARIFI M, HAGHJOOY J S. MiR-30a inhibits melanoma tumor metastasis by targeting the E-cadherin and zinc finger E-box binding homeobox 2[J].Adv Biomed Res,2018,7:143.
[44] 巩茁然,张晓婷,戴志飞.纳米颗粒抑制肿瘤转移的研究进展[J].科学通报,2018,63(15):1482-1492.
[45] YOU L, LIU X, FANG Z, el al. Synthesis of multifunctional Fe3O4@PLGA-PEG nano-niosomes as a targeting carrier for treatment of cervical cancer[J].Mater Sci Eng C Mater for Biol Appl, 2019,94:291-302.
[46] REHMAN F U, DU T Y, SHAIKH S, et al.Nano in nano: biosynthesized gold and iron nanoclusters cargo neoplastic exosomes for cancer status biomarking[J].Nanomedicine, 2018,14(8), 2619-2631.
[47] ROBERTS C M, SHAHIN S A, WEN W, et al.Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models[J].Nanomedicine, 2017, 13(3):965-976.
[48] 赵涛.标记MMPs阳性细胞的光学成像新方法在肿瘤细胞侵袭和转移活性评价中的应用[D].陕西:第四军医大学,2010.
[49] LI Y,FOSS C A, SUMMERFIELD D D,et al.Targeting collagenstrands by photo-triggered triple-helix hybridization[J].Proc Natl Acad Sci USA, 2012, 109(37):14767-14772.
[50] CHEN L Q, HOWISON C M, JEFFERY J J, et al.Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI[J].Magn Reson Med, 2014, 72(5):1408-1417.
[51] SCHMIEDER A H, WINTER P M, WILLIAMS T A, et al.Molecular MR imaging of neovascular progression in the Vx2 tumor with αvβ3-targeted paramagnetic nanoparticles[J].Radiology,2013, 268(2):470-480.

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