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肿瘤超级增强子的作用及其临床意义的研究进展
作者:刘敏1 2  樊红1 
单位:1. 东南大学医学院 遗传与发育生物学系, 江苏 南京 210009;
2. 东南大学 生命科学与技术学院, 江苏 南京 210096
关键词:超级增强子 生物标志物 靶向治疗 肿瘤 综述 
分类号:R730.231
出版年·卷·期(页码):2020·39·第三期(362-365)
摘要:

超级增强子是特异性调节基因表达参与细胞鉴定和人类疾病的一段基因组DNA区域。与经典增强子相比,超级增强子在大小、转录因子密度和含量、激活转录的能力以及对微扰的敏感性等方面不同。超级增强子调控的基因过高表达,为超级增强子及其调控的基因在肿瘤的诊断和治疗中作为标志物提供了可能。本文作者从超级增强子的提出,肿瘤超级增强子的发现与鉴定,超级增强子在肿瘤的临床诊断、治疗、预后评估中的作用等方面的研究进展作一综述。

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