Objective: To investigate the application of tumor specific growth factor(TSGF) in evaluating the severity of renal impairment in patients with chronic kidney disease(CKD). Methods: The clinical data and laboratory indices of 158 cases of patients with CKD(CKD group) and 40 cases of healthy subjects(control group) were analyzed retrospectively. According to the stage of CKD, the patients were subdivided into two groups:mild impairment of renal function group and severe impairment of renal function group. The automatic biochemical analyzer 008AS of HITACHI and the automatic blood cell analyzer XN-1001 of SYSMEX were employed to detect the laboratory indicators. Regression and correlation analysis were used to analyze the correlation of TSGF with levels of CYSC, HCY,D-D, NLR, the stage of CKD and severity of renal impairment in CKD patients. The predictive efficacy of TSGF, CYSC, HCY, NLR and D-D in the diagnosis of early renal impairment in CKD patients was evaluated by comparing the area under the curve(AUC) of receiver operating characteristic(ROC) curve. Results: The levels of TSGF in CKD group were significantly higher than those in control group(P<0.05). TSGF levels in patients with mild impairment of renal function were significantly higher than those in control group(P<0.05), and the levels of TSGF in patients with severe impairment of renal function were significantly higher than those in patients with mild impairment(P<0.05). TSGF was positively correlated with TSGF, CYSC, HCY, NLR, D-D and the stage of patients with CKD(P<0.05). In the ROC curve for predicting early renal impairment in patients with CKD, the AUC of TSGF was significantly greater than that of HCY, NLR and D-D(P<0.05).TSGF was significantly correlated with increased severity of renal function impairment(OR=1.208,95%CI:1.003-1.456,P=0.047). Conclusion: TSGF may be a new biomarker for predicting early renal impairment and evaluating its severity in patients with CKD.
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