Objective: To investigate the application of tumor specific growth factor(TSGF) in evaluating the severity of renal impairment in patients with chronic kidney disease(CKD). Methods: The clinical data and laboratory indices of 158 cases of patients with CKD(CKD group) and 40 cases of healthy subjects(control group) were analyzed retrospectively. According to the stage of CKD, the patients were subdivided into two groups:mild impairment of renal function group and severe impairment of renal function group. The automatic biochemical analyzer 008AS of HITACHI and the automatic blood cell analyzer XN-1001 of SYSMEX were employed to detect the laboratory indicators. Regression and correlation analysis were used to analyze the correlation of TSGF with levels of CYSC, HCY,D-D, NLR, the stage of CKD and severity of renal impairment in CKD patients. The predictive efficacy of TSGF, CYSC, HCY, NLR and D-D in the diagnosis of early renal impairment in CKD patients was evaluated by comparing the area under the curve(AUC) of receiver operating characteristic(ROC) curve. Results: The levels of TSGF in CKD group were significantly higher than those in control group(P<0.05). TSGF levels in patients with mild impairment of renal function were significantly higher than those in control group(P<0.05), and the levels of TSGF in patients with severe impairment of renal function were significantly higher than those in patients with mild impairment(P<0.05). TSGF was positively correlated with TSGF, CYSC, HCY, NLR, D-D and the stage of patients with CKD(P<0.05). In the ROC curve for predicting early renal impairment in patients with CKD, the AUC of TSGF was significantly greater than that of HCY, NLR and D-D(P<0.05).TSGF was significantly correlated with increased severity of renal function impairment(OR=1.208,95%CI:1.003-1.456,P=0.047). Conclusion: TSGF may be a new biomarker for predicting early renal impairment and evaluating its severity in patients with CKD. |
[1] CRAVEDI P,REMUZZI G.Pathophysiology of proteinuria and its value as an outcome measure in chronic kidney disease[J].Br J Clin Pharmacol,2013,76(4):516-523.
[2] CRAVEDI P,RUGGENENTI P,REMUZZI G.Kidney failure stabilizes after an increase over 2 decades[J].J Ren Care,2007,33(3):100-104.
[3] 周美文,徐元宏.慢性肾脏病各期唾液酸、同型半胱氨酸及胱抑素C水平的变化及其临床意义[J].东南大学学报(医学版),2016,35(4):565-568.
[4] KOUKOURAKIS G V,SOTIROPOULOU-LONTOU A.Targeted therapy with bevacizumab(Avastin) for metastatic colorectal cancer[J].Clin Transl Oncol,2011,13(10):710-714.
[5] PRITCHARD C C,GRADY W M.Colorectal cancer molecular biology moves into clinical practice[J].Gut,2011,60(1):116-129.
[6] YU B,XU P Z,WANG Q W,et al.Clinical value of tumour specific growth factor(TSGF) and carbohydrate antigen-125(CA-125) in carcinoma of the endometrium[J].J Int Med Res,2009,37(3):878-883.
[7] SHAO T,HUANG J,ZHENG Z,et al.SCCA,TSGF,and the long non-coding RNA AC007271.3 are effective biomarkers for diagnosing oral squamous cell carcinoma[J].Cell Physiol Biochem,2018,47(1):26-38.
[8] JIANG J T,WU C P,DENG H F,et al.Serum level of TSGF,CA242 and CA19-9 in pancreatic cancer[J].World J Gastroenterol,2004,10(11):1675-1677.
[9] LIANG Y R,WAN D S,CHEN G,et al.Detection of serum tumor supplied group of factors and its clinical significance[J].Chin J Cancer,2002,21(11):1251-1253.
[10] STEVENS L A,CORESH J,GREENE T,et al.Assessing kidney function——measured and estimated glomerular filtration rate[J].N Engl J Med,2006,354(23):2473-2483.
[11] 徐佩,魏雪菲,李菡,等.不同肾小球滤过率估算公式对估算慢性肾脏病患者肾小球滤过率的差异比较[J].现代医学,2018,46(9):978-983.
[12] XU G,LUO K,LIU H,et al.The progress of inflammation and oxidative stress in patients with chronic kidney disease[J].Ren Fail,2015,37(1):45-49.
[13] IMTIAZ F,SHAFIQUE K,MIRZA S S,et al.Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population[J].Int Arch Med,2012,5(1):2.
[14] OKYAY G U,INAL S,ONEÇ K,et al.Neutrophil to lymphocyte ratio in evaluation of inflammation in patients with chronic kidney disease[J].Ren Fail,2013,35(1):29-36.
[15] TONYALI S,CEYLAN C,YAHSI S,et al.Does neutrophil to lymphocyte ratio demonstrate deterioration in renal function?[J].Ren Fail,2018,40(1):209-212.
[16] ZHANG X,LI Y,WU D,et al.Changes serum level of tumor specific growth factor and their clinical significance in mechanical trauma patients[J].J West China Univ Med Sci,2001,32(4):569-571. |