[1] ALYAUTDINl R,KHALIN I,NAFFEEZA M I,et al.Nanoscale drug delivery systems and the blood-brain barrier[J].Int J Nanomedicine,2014,9:795-811.
[2] BHOWMIK A,KHAN R,GHOSH M K.Blood brain barrier:a challenge for effectual therapy of brain tumors[J].Biomed Res Int,2015,2015:320941.
[3] POSADAS I,MONTEAGUDO S,CENA V.Nanoparticles for brain-specific drug and genetic material delivery,imaging and diagnosis[J].Nanomedicine (London),2016,11:833-849.
[4] JONESA R.SHUSTA E V.Blood-brain barrier transport of therapeutics via receptor-mediation[J].PharmRes,2007,24(9):1759-1771.
[5] SRIKANTH M,KESSLER J A.Nanotechnology-novel therapeutics for CNS disorders[J].Nat Rev Neurol,2012,8(6):307-318.
[6] GAO H L,PANG Z Q,JIANG X G.Targeted delivery of nano-therapeutics for major disorders of the central nervous system[J].Pharm Res,2013,30:2485-2498.
[7] BANGHAM A D,STANDISH M M,WATKINS J C.Diffusion of univalent ions across the lamellae of swollen phospholipids[J].J Mol Biol,1965,13(1):238-252.
[8] TIWARIS B,AMIJIM M.A review of nanocarrier-based CNS delivery systems[J].Curr Drug Deliv,2006,3(2):219-232.
[9] LAI F,FADDA A M,SINICO C.Liposomes for brain delivery[J].Expert Opin Drug Deliv,2013,10(7):1003-1022.
[10] SONALI S,SINGH R P,SINGH N,et al.Transferrin liposomes of docetaxel for brain-targeted cancer applications:formulation and brain theranostics[J].Drug Deliv,2016,23(4):1261-1271.
[11] PAPADIA K,GIANNOU A D,MARKOUTSA E.Multifunctional LUV liposomes decorated for BBB and amyloid targeting-B.In vivo brain targeting potential in wild-type and APP/PS1 mice[J].Eur J Pharm Sci,2017,102:180-187.
[12] DENORA N,TRAPANI A,LAQUINTANA V,et al.Recent advances in medicinal chemistry and pharmaceutical technology-strategies for drug delivery to the brain[J].Curr Top Med Chem,2009,9(2):182-196.
[13] LOCKMAN P R,OYEWUMI M O,KOZIARA J M,et al.Brain uptake of thiamine-coated nanoparticles[J].J Control Release,2003,12:271-282.
[14] MENG X,LIU J,YU X,et al.Pluronic F127 and D-α-tocopheryl polyethylene glycol succinate (TPGS) mixed micelles for targeting drug delivery across the blood brain barrier[J].Sci Rep,2017,7(1):2964.
[15] QUADER S,LIU X,CHEN Y,et al.cRGD peptide-installed epirubicin-loaded polymeric micelles for effective targeted therapy against brain tumors[J].J Control Release,2017,258:56-66.
[16] ZAREBKOHAN A,NAJAFI F,MOGHIMI H R,et al.Synthesis and characterization of a PAMAM dendrimer nanocarrier functionalized by SRL peptide for targeted gene delivery to the brain[J].Eur J Pharm Sci,2015,78:19-30.
[17] DHANIKULA R S,ARGAW A,BOUCHARD J F,et al.Methotrexate loaded polyether-copolyester dendrimers for the treatment of gliomas:enhanced efficacy and intratumoral transport capability[J].Mol Pharm,2008,5(1):105-116.
[18] PORTER A E,GASS M,MULLER K,et al.Direct imaging of single-walled carbon nanotubes in cells[J].Nature Nanotechnology,2007,2(10)713-717.
[19] PULSKAMP K,DIABATE S,KRUG H F.Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants[J].Toxicology Letters,2007,168(1):58-74.
[20] SHITYAKOV S,SALVADOR E,PASTORIN G,et al.Blood-brain barrier transport studies,aggregation,and molecular dynamics simulation of multiwalled carbon nanotube functionalized with fluorescein isothiocyanate[J].Nanomedicine,2015,10:1703-1713.
[21] WANG J T,AL-JAMAL K T.Functionalized carbon nanotubes:revolution in brain delivery[J].Nanomedicine (Lond),2015,10(17):2639-2642.
[22] MENG F,ENGBERS G H,FEIJEN J.Biodegradable polymersomes as a basis for artificial cells:Encapsulation,release and targeting[J].Journal of Controlled Release,2005,101(1/2/3):187-198.
[23] LEVINE D H,GHOROGHCHIAN P P,FREUDENBERG J,et al.Polymersomes:a new multi-functional tool for cancer diagnosis and therapy[J].Methods,2008,46(1):25-32.
[24] PANG Z,GAO H,YU Y,GUO L.Enhanced intracellular delivery and chemotherapy for glioma rats by transferrin-conjugated biodegradable polymersomes loaded with doxorubicin[J].Bioconjug Chem,2011,22(6):1171-1180.
[25] QIN Y,CHEN H L,YUAN W M,et al.Liposome formulated with TAT-modified cholesterol for enhancing the brain delivery[J].Pharm,2011,419:85-95.
[26] CHENG Y,DAI Q,MORSHED R A,et al.Blood-brain barrier permeable gold nanoparticles:an efficient delivery platform for enhanced malignant glioma therapy and imaging[J].Small,2014,10:5137-5150.
[27] YAO H,WANG K,WANG Y,et al.Enhanced blood-brain barrier penetration and glioma therapy mediated by a new peptide modified gene delivery system[J].Biomaterials,2015,37:345-352.
[28] KOREN E,TORCHILIN V P.Cell-penetrating peptides:breaking through to the other side[J].Trends Mol Med,2012,18:385-393.
[29] CHEN X,YUAN M,ZHANG Q,et al.Synergistic combination of doxorubicin and paclitaxel delivered by blood brain barrier and glioma cells dual targeting liposomes for chemotherapy of brain glioma[J].Curr Pharm Biotechnol,2016,17(7):636-650.
[30] 张莉,徐维平,苏育德,等.转铁蛋白-转铁蛋白受体在肿瘤主动靶向治疗中的应用[J].中国药业,2012,21(5):1-3.
[31] KUMAR P,WU H Q,MCBRIDE J L,et al.Transvascular delivery of small interfering RNA to the central nervous system[J].Nature,2007,448:39-43.
[32] LI Y,HE H,JIA X R,et al.A dual-targeting nanocarrier based on poly (amidoamine) dendrimers conjugated with transferrin and tamoxifen for treating brain gliomas[J].Biomaterials,2012(2):3899-3908.
[33] LOUREIRO J A,GOMES B,COELHO M A,et al.Targeting nanoparticles across the blood-brain barrier with monoclonal antibodies[J].Nanomedicine (Lond),2014,9:709-722.
[34] MONSALVE Y,TOSI G,RUOZI B,et al.PEG-g-chitosan nanoparticles functionalized with the monoclonal antibody OX26 for brain drug targeting[J].Nanomedicine (Lond),2015,10(11):1735-1750.
[35] KUANG Y Y,AN S,GUO Y B,et al.T7 peptide-functionalized nanoparticles utilizing RNA interference for glioma dual targeting[J].Pharm,2013,454:11-20.
[36] MALETINSKA L,BLAKELY E A,BJORNSTAD K A,et al.Human glioblastoma cell lines:levels of low-density lipoprotein receptor and lowdensity lipoprotein receptor-related protein[J].Cancer Res,2000,60(8):2300-2303.
[37] DEMEULE M,REGINA A,CHE C,et al.Identification and design of peptides as a new drug delivery system for the brain[J].J Pharmacol Exp Ther,2008,324(3):1064-1072.
[38] KAFA H,WANG J T,RUBIO N,et al.Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood-brain barrier in vitro and in vivo[J].J Control Release,2016,225:217-229.
[39] AN S,HE D,WAGNER E,et al.Peptide-like polymers exerting effective glioma-targeted siRNA delivery and release for therapeutic application[J].Small,2015,11(38):5142-5150.
[40] WANG L,HAO Y,LI H,et al.Co-delivery of doxorubicin and siRNA for glioma therapy by a brain targeting system:angiopep-2-modified poly (lactic-co-glycolic acid) nanoparticles[J].J Drug Target,2015,23(9):832-846.
[41] SHILO M,MOTIEI M,HANA P,et al.Transport of nanoparticles through the blood-brain barrier for imaging and therapeutic applications[J].Nanoscale,2014,6:2146-2152.
[42] DIEU L H,WU D,PALIVAN C G,et al.Polymersomes conjugated to 83-14 monoclonal antibodies:in vitro targeting of brain capillary endothelial cells[J].Eur J Pharm Biopharm,2014,88:316-324.
[43] PANZENBOECK U,BALAZS Z,SOVIC A,et al.ABCA1 and scavenger receptor class B,type I,are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells[J].Biol Chem,2002,277:42781-42789.
[44] GAILLARD P J,BRINK A,DE BOER A G.Diphtheria toxin receptor-targeted brain drug delivery[J].Int Congr Ser,2005,1277:185-198.
[45] COSTANTINO L,GANDOLFI F,TOSI G,et al.Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier[J].J Control Release,2005,108:84-96.
[46] 刘庆华,刘彦辰.实用植物本草[M].天津:天津科学技术出版社,1998:256-261.
[47] ZHANG L,HAN L M,QIN J,et al.The use of borneol as an enhancer for targeting aprotinin-conjugated PEG-PLGA nanoparticles to the brain[J].Pharm Res,2013,30:2560-2572.
[48] HYNYNEN K,MCDANNOLD N,VYKHODTSEVA N,et al.Non-invasive MR imaging-guided focal opening of the blood-brain barrier in rabbits[J].Radiology,2001,220(3):640-646.
[49] FAN C H,CHENG Y H,TING C Y,et al.Ultrasound/magnetic targeting with SPIO-DOX microbubble complex for image-guided drug delivery in brain tumors[J].Theranostics,2016,6(10):1542-1556.
[50] LANDIS M S,BOYDER T,PEGG S.Nasal-to-CNS drug delivery:where are we now and where are we heading?An industrial perspective[J].Ther Deliv,2012,3:195-208.
[51] ILLUM L.Transport of drugs from the nasal cavity to the central nervous system[J].Eur J Pharm Sci,2000,11(1):1-18.
[52] YADAV S,GANDHAM S K,PANICUCCI R,et al.Intranasal brain delivery of cationic nanoemulsion-encapsulated TNFα siRNA in prevention of experimental neuroinflammation[J].Nanomedicine,2016,12(4):987-1002. |