目的：探讨甲状腺乳头状癌患者的颈侧区淋巴结转移临床特点。方法：本次研究的对象均为2017年1月至2019年1月来南京大学医学院附属鼓楼医院就诊的甲状腺乳头状癌患者，共206例，回顾性分析其颈侧区淋巴结的转移情况。结果：206例患者均为单叶癌，其中微小癌54例，原发灶直径为4~48 mm，平均为（15.6±5.7）mm。患者颈部颈侧区（Ⅱ、Ⅲ、Ⅳ、Ⅴ）和Ⅵ区的淋巴结转移率分别为54.4%（112例）和71.4%（147例），跳跃性转移率为5.8%（12例）。112例颈侧区淋巴结转移的甲状腺乳头状癌患者中单分区淋巴转移的占33.0%，多分区淋巴结转移的占67.0%。54例微小癌患者中发生Ⅵ区淋巴结转移的有33例（61.1%），发生颈侧区淋巴结转移的有21例（38.9%），未经Ⅵ区而直接发生颈侧区转移的有3例（5.6%）。随访期间，2例患者出现颈部淋巴结转移复发，无病例死亡的情况。结论：甲状腺乳头状癌颈侧区淋巴结转移发生率较高，并且多为多分区淋巴结转移，进行淋巴结清扫时，在常规清扫Ⅵ区淋巴结的基础上可积极尝试扩大淋巴结清扫的范围，这对于改善预后有重要意义。

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