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ApoE基因多态性与缺血性卒中的相关性研究
作者:刘瑷瑜1  张少轲1  谈畅1  杨传坤2  谢春明1  张志珺1 
单位:1. 东南大学医学院/东南大学附属中大医院 神经内科, 江苏 南京 210009;
2. 东南大学附属中大医院 临床检验中心, 江苏 南京 210009
关键词:缺血性卒中 载脂蛋白E 预后 危险因素 
分类号:R743.3
出版年·卷·期(页码):2019·38·第六期(941-946)
摘要:

目的:探讨ApoE基因多态性与缺血性卒中发病的严重程度及预后的相关性。方法:根据ApoE 等位基因分型将缺血性卒中患者分为ApoE ε 2、ApoE ε 3和ApoE ε 4共3组,比较各组间血脂水平、入院时美国国立卫生院神经功能缺损(NIHSS)评分以及出院时改良RANKIN量表(mRS)评分,研究ApoE不同等位基因与缺血性卒中的发病严重程度及预后的相关性。结果:(1)ApoE ε 2组的高密度脂蛋白水平明显高于ApoE ε 3组(P < 0.05)。(2)ApoE ε 4组NIHSS评分明显高于ApoE ε 3组及ApoE ε 2组(P < 0.05)。(3)ApoE ε 4等位基因与急性缺血性卒中预后不良无明显相关(P=0.869)。结论:缺血性卒中患者携带ApoE ε 2等位基因是其保护性因素,而携带ApoE ε 4等位基因可能与缺血性卒中发病的严重程度有一定的相关性。

Objective: To investigate the relationship between the apolipoprotein E (ApoE) gene polymorphism and the severity,prognosis of acute ischemic stroke caused by atherosclerosis. Methods: According to the ApoE allele genotyping, patients with ischemic stroke were divided into 3 groups:ApoE ε 2, ApoE ε 3, and ApoE ε 4 group. Then, the level of lipids, NIHSS scores at admission and mRS scores at discharge were analyzed and compared among each group. Eventually, the relationship between ApoE alleles and the severity,prognosis of ischemic stroke were analyzed. Results: (1) The level of high-density lipoprotein in ApoE ε 2 group were significantly higher than that in ApoE ε 3 group (P < 0.05).(2) The NIHSS scores of the ApoE ε 4 group were significantly higher than that in ApoE ε 3group or ApoE ε 2 group(P < 0.05).(3)Patients carrying ApoE ε 4 allele was not closely related to poor prognosis (P=0.869). Conclusions:ApoE ε 2 allele is a protective factor to ischemic stroke patients. Whereas ApoE ε 4 allele may correlate with the severity of ischemic stroke.

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