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HER2阳性乳腺癌曲妥珠单抗耐药机制及应对策略研究进展
作者:薛玉1  顾军2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东部战区总医院 解放军普通外科研究所, 江苏 南京 210002
关键词:HER2阳性乳腺癌 曲妥珠单抗耐药 机制 策略 综述 
分类号:R737.9
出版年·卷·期(页码):2019·38·第五期(923-928)
摘要:

曲妥珠单抗是人表皮生长因子受体2(HER2)阳性乳腺癌治疗的标准用药,但临床上曲妥珠单抗原发或继发性耐药问题却限制了其疗效,因此了解曲妥珠单抗的耐药机制及应对策略是十分重要的。本文作者从HER2、基因、细胞因子等角度阐述曲妥珠单抗耐药的机制并总结目前最新应对耐药的措施,以期为逆转曲妥珠单抗耐药提供研究方向。

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