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细胞外囊泡作为药物载体的应用前景
作者:徐凯  陈明 
单位:东南大学医学院附属中大医院 泌尿外科, 江苏 南京 210009
关键词:细胞外囊泡 药物载体 靶向治疗 应用前景 综述 
分类号:R310.11
出版年·卷·期(页码):2019·38·第五期(919-923)
摘要:

细胞外囊泡(EVs)作为药物载体具有广阔的应用空间。近年来研究发现EVs作为信号分子在细胞通讯中起重要作用。这些囊泡既可以包裹内源性物质,如RNA、质粒DNA、酶和神经递质等,又可装载外源性治疗药物,像渡轮运送"货物"一样,发挥其天然的载体功能。本文作者综述药物载体的概念,EVs的来源、分类,EVs作为递送系统可携带的物质类型,药物的装载方法及给药途径,EVs作为药物载体的优点和缺点,以及目前其作为药物载体在临床中的应用前景,目的是探寻EVs作为药物载体的发展前景和策略,从而为相关疾病的靶向治疗提供理论依据。

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