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成纤维细胞生长因子23与心血管疾病相关性的研究进展
作者:李晨1  童嘉毅2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 心内科, 江苏 南京 210009
关键词:成纤维细胞生长因子23 心力衰竭 冠心病 左心室肥厚 心肌纤维化 内皮功能障碍 综述 
分类号:R541.4
出版年·卷·期(页码):2019·38·第五期(913-918)
摘要:

成纤维细胞生长因子23(FGF23)是一种主要由成骨细胞和破骨细胞分泌以维持磷酸盐和维生素D的磷酸激素。在慢性肾功能不全的患者中,循环中FGF23的水平明显增加,与左心室肥大(LVH)和冠脉内皮功能障碍以及心血管死亡率增加相关。近来研究表明,FGF23在心肌细胞、血管平滑肌细胞和冠脉内皮细胞等均有表达。因此,FGF23可以在各种临床背景中促进心脏损伤,作者对FGF23与心血管疾病相关性的最新研究进展进行综述。

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