硫氧还蛋白还原酶与冠心病患者介入术后造影剂肾病相关性的研究-东南大学学报医学版

硫氧还蛋白还原酶与冠心病患者介入术后造影剂肾病相关性的研究

单位：东南大学附属中大医院心内科, 江苏南京 210009

分类号：R541.4

出版年·卷·期（页码）：2019·38·第五期（881-885）

摘要：

目的：评估硫氧还蛋白还原酶（TR）与造影剂肾病（CIN）的相关性。方法：收集254例冠心病患者的术前TR水平以及其他基线资料，应用多因素Logistic回归分析CIN的危险因素。结果：共有25例患者发生了CIN，TR低水平组CIN的发生率（15.58%）高于TR高水平组（7.34%，P=0.043）。多元Logistic回归分析显示，TR是CIN的危险因素（OR=0.632，95%CI 0.458~0.871，P=0.005），其他危险因素包括年龄、糖尿病、中性粒细胞与尿酸。结论：低水平的TR可能会增加冠心病患者介入术后CIN的发病风险，但仍需进一步大样本的前瞻性研究证实。

Objective: To explore the association between thioredoxin reductase(TR) and contrast induced nephropathy(CIN) in order to provide new ways for prevention and treatment of CIN. Methods: The TR level before coronary artery intervention and other basic data of 254 coronary heart disease patients were collected to predict the risk factors of CIN by multivariate Logistic regression analysis. Results: CIN occurred in 25 patients. The incidence rate of CIN in TR low-level group(15.58%) was higher than that in high-level group(7.34%,P=0.043). Multivariate Logistic regression analysis showed that TR was a risk factor of CIN(OR=0.632,95%CI 0.458-0.871, P=0.005). Other risk factors included age, diabetes mellitus, neutrophil and uric acid. Conclusion: The low-level TR may increase the incidence risk of CIN after coronary artery intervention in coronary heart disease patients. But it still needs to be confirmed by large sample prospective research.

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