滋阴平肝补肾法配合针灸治疗肝肾阴虚型围绝经期综合征的临床疗效-东南大学学报医学版

滋阴平肝补肾法配合针灸治疗肝肾阴虚型围绝经期综合征的临床疗效

单位：承德医学院附属医院中医科, 河北承德 067000

分类号：R271.1

出版年·卷·期（页码）：2019·38·第四期（672-676）

摘要：

目的：探讨滋阴平肝补肾自拟方配合针灸对肝肾阴虚型围绝经期综合征患者临床症状的改善，及其对生殖内分泌激素水平的影响。方法：选取104例符合西医围绝经期诊断及中医肝肾阴虚证型诊断的患者，将患者分为中药对照组（38例）、针灸对照组（31例）和联合组（35例），中药对照组患者服用滋阴平肝补肾汤，针灸对照组患者实施针灸治疗，联合组患者服用滋阴平肝补肾汤配合针灸治疗。每组患者于治疗前后采用Kupperman评分、中医肝肾阴虚证候积分评价临床疗效，检测治疗前后血清雌二醇（E₂）、促卵泡生成素（FSH）、促黄体生成素（LH）水平。结果：3组患者Kupperman评分及中医肝肾阴虚证候积分治疗后均低于治疗前（P<0.05），联合组显著低于中药对照组与针灸对照组（均P<0.05）。与治疗前比较，3组血清E₂水平均显著升高（P<0.05），FSH、LH水平均显著下降（P<0.05）。联合组血清E₂水平显著高于中药对照组与针灸对照组（P<0.05），FSH水平显著低于中药对照组与针灸对照组（P<0.05）。结论：滋阴平肝补肾法配合针灸治疗肝肾阴虚型围绝经期综合征可缓解其临床症状，有效提高围绝经期患者血清E₂水平，降低血清FSH、LH水平。

Objective: To investigate the clinical efficacy of Ziyin Pinggan Bushen decoction with acupuncture in patients with perimenopausal syndrome of liver and kidney Yin deficiency. Methods: 104 patients were randomly divided into prescription control group, acupuncture control group and combination group. The prescription control group was treated with Ziyin Pinggan Bushen decoction. Acupuncture treatment was performed in the acupuncture control group. The combination group was treated with Ziyin Pinggan Bushen decoction and acupuncture treatment. Score of Kupperman and points of liver and kidney Yin deficient syndrome were used to evaluate before and after trentment, and levels of serum E₂, FSH and LH were detected before and after treatment. Results: After treatment, both score of Kupperman and points of liver and kidney Yin deficient syndrome were lower than before treatment(P<0.05). The combination group was significantly better than the prescription control group and the acupuncture control group(P<0.05). Compared with before treatment, levels of serum E₂ in the three groups were increased significantly (P<0.05), and levels of FSH and LH were decreased significantly (P<0.05). The level of serum E₂ in the combination group was significantly higher than that in the prescription control group and the acupuncture control group (P<0.05), and the level of FSH was significantly lower than that in the prescription control group and the acupuncture control group (P<0.05). Conclusion: Ziyin Pinggan Bushen decoction cooperated with acupuncture can relieve the clinical symptoms of liver and kidney Yin deficient perimenopausal syndrome, and effectively improve the level of serum E₂ and reduce level of serum FSH and LH in patients with perimenopausal syndrome.

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