山西人群维生素D水平与2型糖尿病的相关性研究-东南大学学报医学版

山西人群维生素D水平与2型糖尿病的相关性研究

单位：1. 山西医科大学基础医学院微生物学与免疫学教研室, 山西太原 030000;
2. 山西省中医院检验科, 山西太原 030000

分类号：R587.1

出版年·卷·期（页码）：2019·38·第四期（628-632）

摘要：

目的：探讨山西人群中维生素D水平与2型糖尿病（T2DM）之间的关系。方法：选取196例T2DM患者为T2DM组，同期选取99例健康体检者作为对照组。检测血清25羟维生素D₃[25（OH）D₃]、糖代谢指标[空腹血糖（FPG）、胰岛素（FINS）、糖化血红蛋白（HbA_1c）]、C肽以及脂代谢指标[甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）]水平。结果：T2DM组血清25（OH）D₃水平明显低于对照组（P<0.01）；维生素D水平变化具有明显季节特性（P<0.01）；相关分析显示维生素D水平与FPG、HbA_1C、C肽之间呈负相关，与FINS无相关性；调整混杂因子后Logistic回归分析显示，与维生素D水平正常[25（OH）D₃≥30 ng·ml^-1]的人群相比，维生素D水平缺乏和不足[25（OH）D₃<30 ng·ml^-1]的人群患T2DM的风险增加（OR=2.46，95%CI为1.18~5.16）。结论：山西人群T2DM患者中普遍存在维生素D缺乏的现象，并且具有明显的季节特性。

Objective: To explore the status of serum 25-hydroxyvitamin D[25(OH)D₃] and the relationship with type 2 diabetes mellitus(T2DM) in Shanxi. Methods: A total of 196 patients with T2DM were enrolled in this study. In the same period, 99 healthy people were selected as the control group. Serum 25(OH)D₃ levels and glucose, lipid metabolism indicators were measured. Results: Serum 25(OH)D₃ concentration in patients with T2DM was significantly lower than that in the control group (P<0.01). Serum 25(OH) D₃ levels were associated with seasonal variation in both healthy and T2DM population (P<0.01). Correlation analysis showed that there was a negative correlation between 25(OH)D₃ and FPG, HbA_1C, C peptide, and no correlation with FINS. The risk of having T2DM increased significantly when vitamin D levels decreased from ≥ 30 ng·ml^-1 to <30 ng·ml^-1 after adjustment for confounders (OR=2.46, 95%CI: 1.18-5.16). Conclusion: Vitamin D deficiency is prevalent in Shanxi population and has obvious seasonal characteristics.

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