Objective:To investigate the effect of sufentanil combined with dexmedetomidine on systemic inflammatory response syndrome(SIRS) score and sleep quality of patients after abdominal hysterectomy. Methods:Seventy-two patients with abdominal hysterectomy were selected and randomly divided into two groups,i.e., the combined group(sufentanil and dexmedetomidine) and the single group(sufentanil)with 36 cases in each group. The sleep distribution(non-REM sleep phases and REM sleep phases), subjective sleep quality and sleep efficiency of the two groups were compared for 3 consecutive nights(21:00 in the evening to 6:00 the next day of 1 night before surgery, 1 and 2 nights after surgery). The SIRS scores of the two groups were compared. Results:The sleep of non-rapid eye movement stage I was significantly higher in the single drug group on the first night and the second night after surgery than that on the night before surgery(P<0.05), while the sleep of non-rapid eye movement stage Ⅱ was significantly higher in the combined drug group(P<0.05). The rapid eye movement period on the first and the second night after surgery was significantly lower than that on the night before surgery(P<0.05), but there was no statistical difference between the two groups(P>0.05). The sleep, sleep efficiency, arousal index and subjective sleep quality in slow wave sleep phase of non-rapid eye movement sleep on the first and the second night after operation of the two groups were significantly lower than those on the night before operation(P<0.05), and there were statistically significant differences between the two groups(P<0.05). Compared with the single drug group, the postoperative SIRS score in the combined drug group was significantly lower(P<0.05). Conclusion:For patients with sleep deprivation after abdominal hysterectomy, combined administration of sufentanil and dexmedetomidine can lower SIRS score and improve sleep quality, which is better than single administration.
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