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间充质干细胞治疗诱导单核细胞/巨噬细胞表型转换作用的研究进展
作者:吴菲菲1  季晶晶1  陆文彬1 2  马根山1 2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 心血管内科, 江苏 南京 210009
关键词:心肌梗死 间充质干细胞 单核细胞 巨噬细胞 综述 
分类号:R329.2;R542.22
出版年·卷·期(页码):2019·38·第二期(363-367)
摘要:

急性心肌梗死(AMI)后心肌细胞凋亡坏死,不能有效代偿,引起心肌重塑,导致心力衰竭的发展。为了减少瘢痕组织形成并刺激心脏组织的再生,间充质干细胞(MSC)已经在AMI后应用并且显示出对心脏功能的益处。研究发现AMI后对炎症反应的调节,特别是与单核细胞/巨噬细胞的作用相关,是MSC治疗的重要方面。单核细胞和巨噬细胞用不同表型刺激或抑制炎症与心肌重塑,对心血管疾病病理生理学的重要贡献引起了人们的极大关注。为了更深入地了解MSC的这种作用,在本文中作者就MSC对单核细胞/巨噬细胞的这种调节作用作一综述。

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