Objective:To analyze the effect of budesonide combined pulmonary surfactant (PS) in treating intrauterine infection neonatal respiratory distress syndrome (NRDS) children and the influence on serum Clara cell secretory protein 16 (CC16), surfacetant protein-A (SP-A). Methods:100 NRDS children were randomly divided into control group and observation group(n=50). Control group was treated with PS, observation group was treated with budesonide combined PS. The clinical effect, QI-blood indexes, serum CC16, SP-A were compared. Results:The effective rate of observation group was 90.0%, which was higher than that of control group (74.0%, P<0.05). After treatment, QI-blood indexes of both groups were improved, but observation group's PaO2, OI were higher than those of control group,PaCO2 was lower than that of control group(P<0.05). After treatment, both groups' serum CC16, SP-A were decreased(P<0.05), and that of observation group was significantly lower(P<0.05). The mechanical ventilation rate and bronchopulmonary dysplasia rate of observation group were significantly lower (P<0.05). Conclusion:Budesonide combined PS can improve the clinical effect, decrease serum CC16, SP-A. |
[1] WANG J,LIU X,ZHU T,et al.Analysis of neonatal respiratory distress syndrome among different gestational segments[J].Int J ClinExp Med,2015,8(9):16273-16279.
[2] YEH T F,CHEN C M,WU S Y,et al.Intratracheal administration of budesonide/surfactant to prevent bronchopulmonary dysplasia[J].Am J Respir Crit Care Med,2016,193(1):86-95.
[3] 王冉,张巧,马千里,等.血清学生物标志物对急性呼吸窘迫综合征进展及预后的预测研究[J].第三军医大学学报,2017,39(19):1926-1932.
[4] 李政.肺表面活性蛋白A、D水平监测在间质性肺疾病诊治中的临床价值[J].临床和实验医学杂志,2017,16(2):173-175.
[5] 胡亚美,江载芳,陆华,等.诸福棠实用儿科学[M].7版.北京:人民卫生出版社,2012:458-461.
[6] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].4版.北京:人民卫生出版社,2011:395-398.
[7] SWEENEY R M,MCAULEY D F.Acute respiratory distress syndrome[J].Lancet,2016,388(10058):2416-2430.
[8] 穆静.呼吸支持对新生儿呼吸窘迫综合征治疗效果及危险因素分析[J].现代医学,2014,42(9):1051-1054.
[9] 曹冰冰,黄为民.糖皮质激素防治新生儿支气管肺发育不良利弊研究进展[J].中国妇幼保健,2016,31(7):1557-1560.
[10] FENG Y,KUMAR P,WANG J,et al.Dexamethasone but not the equivalent doses of hydrocortisone induces neurotoxicity in neonatal ratbrain[J].Pediatr Res,2015,77(5):618-624.
[11] 陈海英,乔娅.布地奈德联合特布他林雾化吸入对小儿支原体肺炎的疗效及对肺功能的影响[J].现代医学,2018,46(10):1115-1118.
[12] BARRETTE A M,ROBERTS J K,CHAPIN C,et al.Antiinflammatory effects of budesonide in human fetal lung[J].Am J Respir Cell Mol Biol,2016,55(5):623-632.
[13] 吕丽辉,杨玉波,付言杰,等.血清CC-16水平用于ARDS患者预后的临床价值研究[J].医学研究杂志,2017,46(7):140-145.
[14] 张辉果,王晓利,董志巧,等.感染性肺炎患儿血清及灌洗液中肺表面活性蛋白及炎性介质水平的变化研究[J].中华医院感染学杂志,2017,27(3):663-666.
[15] YANG C F,LIN C H,CHIOU S Y,et al.Intratracheal budesonide supplementation in addition to surfactant improves pulmonary outcome in surfactant-depleted newborn piglets[J].PediatrPulmonol,2013,48(2):151-159. |
