[1] ZHANG H,PULESTON D J,SIMON A K.Autophagy and immune senescence[J].Trends Mol Med,2016,22(8):671-686.
[2] LOPEZ-OTIN C,BLASCO M A,PARTRIDGE L,et al.The hallmarks of aging[J].Cell,2013,153(6):1194-1217.
[3] NEVES J,SOUSA-VICTOR P,JASPER H.Rejuvenating strategies for stem cell-based therapies in aging[J].Cell Stem Cell,2017,20(2):161-175.
[4] KFOURY Y,SCADDEN D T.Mesenchymal cell contributions to the stem cell niche[J].Cell Stem Cell,2015,16(3):239-253.
[5] WAGNER W,HORN P,CASTOLDI M,et al.Replicative senescence of mesenchymal stem cells:a continuous and organized process[J].PLoS One,2008,3(5):e2213.
[6] GANGARAJU V K,LIN H.MicroRNAs:key regulators of stem cells[J].Nat Rev Mol Cell Biol,2009,10(2):116-125.
[7] SCHOEFTNER S,SCAROLA M,COMISSO E,et al.An Oct4-pRb axis, controlled by MiR-335, integrates stem cell self-renewal and cell cycle control[J].Stem Cells,2013,31(4):717-728.
[8] VOORHOEVE P M,LE SAGE C,SCHRIER M,et al.A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors[J].Cell,2006,124(6):1169-1181.
[9] OKADA M,KIM H W,MATSU-URA K,et al.Abrogation of age-induced microRNA-195 rejuvenates the senescent mesenchymal stem cells by reactivating telomerase[J].Stem Cells,2016,34(1):148-159.
[10] ROBERTS T C.The microRNA biology of the mammalian nucleus[J].Mol Ther Nucleic Acids,2014,3:1-8.
[11] LIU H,LEI C,HE Q,et al.Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer[J].Mol Cancer,2018,17(1):64.
[12] WANG L,FENG Z,WANG X,et al.DEGseq:an R package for identifying differentially expressed genes from RNA-seq data[J].Bioinformatics,2010,26(1):136-138.
[13] DWEEP H,GRETZ N.miRWalk2. 0:a comprehensive atlas of microRNA-target interactions[J].Nat Methods,2015,12(8):697.
[14] BINDEA G,GALON J,MLECNIK B.CluePedia Cytoscape plugin:pathway insights using integrated experimental and in silico data[J].Bioinformatics,2013,29(5):661-663.
[15] MEIRELLES L D S,FONTES A M,COVAS D T,et al.Mechanisms involved in the therapeutic properties of mesenchymal stem cells[J].Cytokine Growth Factor Rev,2009,20(5-6):419-427.
[16] BOREGOWDA S V,BOOKER C N,PHINNEY D G.Mesenchymal stem cells:the moniker fits the science[J].Stem Cells,2017,36(1):7-10.
[17] 颜明露,李洋.异基因间充质干细胞移植在类风湿关节炎中的研究进展[J].现代医学,2017,45(7):992-995.
[18] RODIER F,CAMPISI J.Four faces of cellular senescence[J].J Cell Biol,2011,192(4):547-556.
[19] 岑双庆,刘宇,高雪华,等.人脐带间充质干细胞体外传代遗传特性的研究[J].现代医学,2015,43(9):1093-1098.
[20] BENHAMED M,HERBIG U,YE T,et al.Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells[J].Nat Cell Biol,2012,14(3):266-275.
[21] WEINBERG M S,MORRIS K V.Transcriptional gene silencing in humans[J].Nucleic Acids Res,2016,44(14):6505-6517.
[22] MATSUI M,CHU Y,ZHANG H,et al.NAR breakthrough article:promoter RNA links transcriptional regulation of inflammatory pathway genes[J].Nucleic Acids Res,2013,41(22):10086-10109.
[23] MENG X,XUE M,XU P,et al.MicroRNA profiling analysis revealed different cellular senescence mechanisms in human mesenchymal stem cells derived from different origin[J].Genomics,2017,109(3-4):147-157.
[24] CONSORTIUM S.A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control consortium[J].Nat Biotechnol,2014,32(9):903-914.
[25] ZHAO W,LIN Z,ZHANG Z.Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibroblasts[J].Cell Res,2004,14(1):60-66.
[26] TURINETTO V,VITALE E,GIACHINO C.Senescence in human mesenchymal stem cells:functional changes and implications in stem cell-based therapy[J].Int J Mol Sci,2016,17(7):1-18. |