肺癌化疗后心肺并发症的发生与治疗前轻度肺功能降低的相关性研究-东南大学学报医学版

肺癌化疗后心肺并发症的发生与治疗前轻度肺功能降低的相关性研究

单位：河北医科大学第四医院功能科, 河北石家庄 050000

分类号：R734.2

出版年·卷·期（页码）：2019·38·第一期（164-168）

摘要：

目的：探究肺癌患者化疗前轻度肺功能降低与化疗后心肺并发症（PCC）的相关性，为临床肺癌患者化疗效果提供预测参考。方法：回顾性分析我院150例行化疗的肺癌患者的临床资料。根据患者化疗后1个月内有无心肺并发症分为PCC组和无PCC对照组，探究化疗前轻度肺功能不全与患者化疗后并发症的相关性，同时探讨肺通气相关指标（FEV1%、FVC%）轻度降低与化疗后PCC的关系。结果：150例患者正常、轻度及中重度肺功能不全分别有25例、36例和89例，发生PCC患者共有82例，各组化疗后1个月内PCC发生率分别为20%、61.11%和61.80%，差异具有统计学意义（χ²=14.553，P=0.001）。化疗前FEV1%轻度减低（≥ 70%）或FVC%轻度减低（≥ 70%）与化疗后PCC的发生相关（P=0.019，P=0.011）。结论：化疗前，FEV1%和FVC%同时轻度降低是影响肺癌化疗后PCC的危险因素。

Objective:To explore the correlation between mild reduction of pulmonary function before chemotherapy and postoperative cardiopulmonary complication (PCC) after chemotherapy in patients with lung cancer, aiming at providing a predictive reference for the chemotherapy effect in the patients with lung cancer. Methods:Clinical data of 150 patients with lung cancer who received chemotherapy in our hospital were analyzed. Patients were assigned to PCC group and non-PCC control group depending on occurrence of cardiopulmonary complications within 1 month after chemotherapy. The correlation between mild pulmonary dysfunction before chemotherapy and postoperative complications after chemotherapy was explored, and the relationship between mild reduction of pulmonary ventilation related indices (FEV1%, FVC%) and PCC after chemotherapy was also discussed. Results:25, 36 and 89 out of these 150 cases were with normal pulmonary function, mild pulmonary dysfunction and moderate severe pulmonary dysfunction respectively and 82 out of 150 patients with PCC. The occurring rates of PCC in each group in 1 month after chemotherapy were 20%, 61.11% and 61.80% respectively. The differences were statistically significant(χ²=14.553,P=0.001). There was a relation between slight decrease of FEV1% decrease (≥ 70%) or FVC%(≥ 70%) before chemotherapy and the occurrence of PCC after chemotherapy (P=0.019, P=0.011). Conclusion:The simultaneous mild decrease of FEV1% and FVC% before chemotherapy is a risk factor for PCC in lung cancer after chemotherapy.

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