Objective:To detect the expression of NLRP3, Caspase-1, IL-1β and IL-18 in the serum of preeclampsia patients and to explore its clinical relevance with preeclampsia. Methods:A total of 320 single pregnant women of Han nationality were included in the obstetrics department of Zhongda hospital affiliated to southeast university from January 2016 to January 2018. They were divided into two groups:preeclampsia group(160 cases)and control group(160 cases). The clinical data of the subjects were compared and the risk factors of PE were analyzed. 30 single pregnant women of Han nationality between July 2017 and December 2017 were selected, including 15 cases of early onset preeclampsia and 15 cases in control. The serum levels of NLRP3, Caspase-1, IL-1βand IL-18 were measured by ELISA. Results:1. There were statistically significant differences in age, partner age, education level, pre-pregnancy weight and body mass index(BMI), pre-childbirth weight and BMI and family history of hypertension between the two groups(P<0.05). 2. The serum levels of NLRP3, Caspase-1, IL-1 serum and IL-18 in pregnant women with early-onset PE were all increased compared with the control group, and the serum level of IL-1 was statistically significant(P<0.05). Conclusion:1. Low educational level, high pre-pregnancy BMI and family history of hypertension are the independent risk factors of PE. 2. There is an important relevance between pyroptosis and the pathogenesis of PE, which may be a new target for the treatment of PE.
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