Objective:To investigate the effect of asphyxia on erythrocyte parameters in preterm infants, and whether nucleated red blood cells (NRBC) can predict hypoxic brain damage and prognosis in premature infants. Methods:Fifity asphyxia premature infants with brain injury and 30 asphyxia premature infants without brain injury were selected as observation group, and 20 preterm infants as control group from June 2015 to May 2017. Blood routine red blood cell parameters were detected at different time points in the two groups. We also had MRI, amplitude integrated electroencephalogram and head color Doppler examination. The brain damage in preterm infants was observed dynamically. Results:The number of red blood cells (RBC), HGB, HCT had no statistical significance between the observation group and the control group (P>0.05). NRBC and NRBC% of the observation group were significantly higher than that in the control group (P<0.05); Amplitude integrated electroencephalogram (Co) EEG continuity, sleep wake cycle (Cy) and edge amplitude (LB) of the observation group were significantly lower than the control group (P<0.05). The cerebral blood flow velocity of the observation group was significantly lower than that of the control group (P<0.05). The NRBC parameters returned to normal in 12 months after birth, and the percentage of brain injury decreased significantly (P<0.05). The increase of NRBC was positively correlated with the degree of asphyxia. The level of NRBC was positively correlated with the degree of asphyxia preterm infants. Conclusion:The degree of NRBC elevation in asphyxiated premature infants is associated with the degree of asphyxia. The time of NRBC returned to normal in asphyxia premature infants is positively correlated with the recovery time of cranial imaging and EEG abnormality. It can be used as an index to predict the degree and prognosis of brain injury.
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