Objective:To explore the efficacy and mechanism of anticoagulant combined with statins in the treatment of steroid induced osteonecrosis of the femoral head in rats. Methods:Rats were divided into three groups:control group, model group and observation group. The steroid-induced femoral head necrosis model was induced by Escherichia coli endotoxin and methylprednisolone. After the model was duplicated, warfarin and Atto vastatin were administered intragastrically in the observation group. The morphology, femoral head X-ray findings, bone mineral density, serum phosphorus, calcium and vascular endothelial growth factor (VEGF) levels, plasma total cholesterol (Tch) test box and low density lipoprotein (LDL) levels were compared in each group. Results:Compared with the model group, the mental state, color of the hair and activity in the observation group were significantly improved, the gross morphology of the femoral head was improved effectively, the bone density was uniform, and the femoral head was smooth, trabecular bone was clear; After model replication, the bone mineral density (BMD), serum phosphorus and calcium levels in the observation group were significantly higher than those in the model group (P<0. 05). The levels of serum phosphorus and calcium in the observation group were significantly higher than those in the model group (P<0.05), and the levels of VEGF in the observation group were significantly higher than those in the model group (P<0. 05). The levels of plasma PT and t-PA, serum TCH and LDL in the observation group were significantly lower than those in the model group (P<0. 05). Conclusion:Anticoagulant therapy combined with lipid-lowering in the treatment of steroid-induced femoral head necrosis can have a significant effect through the mechanism of lowering lipid and anticoagulation to improve blood circulation, promote blood vessel regeneration and bone cell growth. |
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