前列腺癌组织B7-H4蛋白表达水平及其与患者不良预后的关系-东南大学学报医学版

前列腺癌组织B7-H4蛋白表达水平及其与患者不良预后的关系

单位：山西医科大学汾阳学院临床医学系泌尿外科, 山西汾阳 032200

分类号：R737.25

出版年·卷·期（页码）：2019·38·第一期（103-108）

摘要：

目的：探讨B7-H4在前列腺癌组织中的表达及其预后意义。方法：采用免疫组织化学染色检测72例前列腺癌和50例良性前列腺增生组织B7-H4蛋白表达水平，Kaplan-Meier检验计算B7-H4表达与前列腺癌总体生存率的关系，Cox比例风险模型分析影响患者预后的因素。结果：前列腺癌组织B7-H4高表达率为83.3%（60/72），前列腺增生组织为32.0%（16/50），前列腺癌组织B7-H4高表达率明显高于前列腺增生组织（χ²=33.105，P<0.001）。B7-H4在Gleason评分8~10分中的阳性表达率明显高于2~7分组，Ⅲ-Ⅳ组B7-H4阳性表达率明显高于Ⅰ-Ⅱ组，淋巴结转移组B7-H4阳性表达率明显高于无淋巴结转移组（P<0.05）。Gleason评分越高，中位生存期越短；Ⅲ-Ⅳ期中位生存期明显低于Ⅰ-Ⅱ期，淋巴结转移的患者中位生存期更短，B7-H4高表达越高中位生存期明显低于B7-H4低表达（均P<0.05）；Gleason评分、TNM分期、淋巴结转移、B7-H4蛋白是影响前列腺癌患者预后的独立危险因素（均P<0.05）。结论：前列腺癌组织中B7-H4呈高表达，可以作为前列腺癌预后评估的分子标志物之一。

Objective:To explore the expression of B7-H4 in prostate cancer tissue and its value as a prognostic biomarker for poor survival. Methods:The protein expression of B7-H4 was measured by immunohistochemistry assay in 72 prostate cancer tissues and 50 benign prostatic hyperplasia tissues, the relationship between B7-H4 expression and over-all survival in prostate cancer patients was identified by Kaplan-Meier, the prognostic factors of patients were calculated by Cox proportional hazard regression model. Results:The high expression rate of B7-H4 in the prostate cancer group was 83.3% (60/72), while 32.0% (16/50) in the prostatic hyperplasia group, the high expression rate of B7-H4 in the prostate cancer group was significantly lower than that in the prostatic hyperplasia group, the difference was statistically significant (χ²=33.105, P<0.001). The high expression rate of B7-H4 in the 8-10 score group was markedly than that in the 2-7 score group, it was higher in Ⅲ-Ⅳ group than in the Ⅰ-Ⅱ group, also it was obviously higher in lymph node metastasis group was obviously higher than in the non-lymph node metastasis group, the difference was statistically significant (P<0.05). The median survival in the prostate cancer patients was negatively correlated with the Gleason score, TNM stage, lymph node metastasis and B7-H4 expression (all P<0.05). Besides, Gleason score, TNM stage, lymph node metastasis and B7-H4 were independent risk factors for the poor prognostic of prostate cancer (all P<0.05). Conclusion:The expression of B7-H4 is up-regulated in the prostate cancer, and its can be used as a biomarker for prognostic of prostate cancer patients.

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