Objective:To explore the relationship between serum matrix gla protein(MGP) levels and coronary artery calcification(CAC), and to provide evidence for the clinical diagnosis and evaluation of CAC. Methods:A total of 86 patients with coronary heart disease were eligible for this study from May 2017 to April 2018. The levels of serum MGP were determined in their fasting blood samples after admission. CT coronary angiography was performed with a 64-slice CT. According coronary artery calcium score, all patients were divided into calcification group (CACS>0) and control group(CACS=0). According CACS value, calcification group were further divided into four groups:slight calcification group(CACS<10), mild calcification group(CACS=10-99.9), moderate calcification group(CACS=100-399.9), severe calcification group(CACS ≥ 400).The difference of serum MGP levels was compared between the groups, and the correlation between serum MGP levels and the degree of coronary artery calcification were analyzed. Results:There were no significant differences of serum MGP levels between the slight calcification group, the mild calcification group and the control group(23.0±3.59 vs 23.6±4.58 nmol·L-1;22.8±4.02 vs 23.6±4.58 nmol·L-1,P>0.05). The serum level of MGP in the moderate calcification group and severe the calcification group were all lower than that in the control group(16.4±3.78 vs 23.6±4.58 nmol·L-1,P<0.05;11.3±2.96 vs 23.6±4.58 nmol·L-1,P<0.01). There were significant differences of serum MGP levels among the mild calcification group, the moderate calcification group and the severe calcification group(P<0.05). There was a significant negative correlation between MGP levels and coronary artery calcium score(r=-0.023,P<0.05). Multivariate logistic regression analysis showed that the history of diabetes, cholesterol, low density lipoprotein and MGP were the independent risk factors of CAC. Conclusion:Serum MGP negatively correlated with coronary artery calcification,is the independent predictor for diagnosis and assessment of coronary artery calcification degree.
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