D-二聚体与急性心肌梗死冠脉病变程度的相关性研究-东南大学学报医学版

D-二聚体与急性心肌梗死冠脉病变程度的相关性研究

单位：1. 东南大学医学院, 江苏南京 210009;
2. 东南大学附属中大医院心血管内科, 江苏南京 210009

分类号：R542.2+2

出版年·卷·期（页码）：2019·38·第一期（63-67）

摘要：

目的：探讨D-二聚体与急性心肌梗死（AMI）及冠脉病变程度的关系。方法：选取2015年1月至2017年11月就诊于东南大学附属中大医院心内科的急性心肌梗死患者387例（AMI组）及同期经冠脉造影检查阴性的非冠心病患者45例（对照组），比较两组D-二聚体水平的差异，并根据冠脉造影结果，计算AMI组患者冠脉病变支数及Gensini评分，比较其与D-二聚体之间的相关性。结果：（1）AMI组D-二聚体水平高于对照组D-二聚体水平（P<0.05）。（2）双支病变组D-二聚体水平、三支病变组D-二聚体水平均高于单支病变组D-二聚体水平（P<0.05），三支病变组D-二聚体水平高于双支病变组D-二聚体水平（P<0.05）。（3）D-二聚体水平与Gensini评分呈高度正相关（r=0.934，P<0.05）。结论：AMI组血浆D-二聚体水平明显高于对照组，且D-二聚体与冠状动脉病变程度呈正相关。

Objective:To investigate the correlation between D-dimer and degree of coronary lesions in patients with acute myocardial infarction(AMI). Methods:A total of 432 patients were chosen in the affiliated hospital of Southeast University from January 2015 to November 2017, who were divided into two groups, AMI group(n=387) and control group (n=45). The level of plasma D-dimer in the two groups was compared. According to the results of coronary angiography, AMI group was divided into single vessel lesion group, double vessel lesion group and triple vessel lesion group. The plasma D-dimer levels among these three subgroups were compared. The degree of coronary stenosis was assessed by the Gensini score. Results:(1) The plasma D-dimer level in AMI group was higher than that in the control group(P<0.05). (2) The plasma D-dimer level in the single vessel lesion group was different from that in the other two sub-groups (P<0.05). The plasma D-dimer level in triple vessel lesion group was higher than that in double vessel lesion group (P<0.05). (3) The level of plasma D-dimer was positively correlated with Gensini score in the AMI group (r=0.934,P<0.05). Conclusion:The plasma D-dimer level in the AMI group was higher than that in the control group, and there was a positive correlation between D-dimer level and coronary artery lesion degree.

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