急性冠脉综合征患者血清磷脂转运蛋白活性与N末端脑钠肽前体水平的相关性及预后意义-东南大学学报医学版

急性冠脉综合征患者血清磷脂转运蛋白活性与N末端脑钠肽前体水平的相关性及预后意义

单位：1. 无锡市锡山人民医院心血管内科, 江苏无锡 214011;
2. 东南大学附属中大医院心血管内科, 江苏南京 210009

分类号：R546.1+1

出版年·卷·期（页码）：2019·38·第一期（57-63）

摘要：

目的：分析急性冠脉综合征（ACS）患者血清磷脂转运蛋白（PLTP）活性与N末端脑钠肽前体（NT-proBNP）水平的相关性及预后意义。方法：2014年至2016年期间，无锡市锡山人民医院心血管内科顺序入选ACS患者121例，测定PLTP活性和NT-proBNP水平、行心脏彩超及常规实验室检验，随访一年。结果：高NT-proBNP水平患者PLTP活性明显高于低NT-proBNP水平患者，多重线性回归提示NT-proBNP水平与PLTP活性相关（Beta=0.214，P=0.014）。左室收缩功能降低患者PLTP活性与NT-proBNP水平明显增高。Logistic回归分析提示高PLTP活性（OR=1.024，P=0.000）与高NT-proBNP水平（OR=1.000，P=0.027）是不良心脏事件的独立预测因子。ROC曲线显示高PLTP活性与高NT-proBNP水平预测不良心脏事件发生的曲线下面积分别为0.798与0.757。结论：ACS患者血清PLTP活性与NT-proBNP水平相关且能预测不良心脏事件的发生。

Objective:To investigate the association between serum phospholipid transfer protein (PLTP) activity and N-terminal pro brain natriuretic peptide (NT-proBNP) levels and whether these biomarkers could predict adverse cardiac events at 12-month follow-up in patients with acute coronary syndrome (ACS). Methods:A total of 121 ACS patients were recruited in the Xishan People's Hospital of Wuxi from June 2014 to June 2016, PLTP activity and NT-proBNP levels were measured. Patients were followed-up for one year, and information on adverse cardiac events was collected. Results:PLTP activity levels were significantly higher in patients with high NT-proBNP levels than that in patients with low NT-proBNP levels. Multiple linear regression analysis showed that high NT-proBNP levels were associated with PLTP activity (Beta=0.214, P=0.014). Patients with left ventricular systolic dysfunction had high PLTP activity and NT-proBNP levels. Logistic regression analysis revealed that increased PLTP activity (OR=1.024, P=0.000) and NT-proBNP levels (OR=1.000, P=0.027) independently predicted adverse cardiac events. The area under the curve of high PLTP activity and high NT-proBNP level in predicting adverse cardiac events were 0.798 and 0.757, respectively. Conclusion:Serum PLTP activity was associated with NT-proBNP levels, and they further reflected the adverse cardiac events in the ACS patients.

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