Objective:To investigate the effect of metoprolol on arrhythmia, serum myocardial enzymes and inflammatory factors. Methods:One hundred and five children with arrhythmia admitted in our hospital from June 2014 to April 2017 were enrolled in this study and randomly divided into 2 groups:51 cases was given myocardial nutrition therapy(control group) and 54 cases was given metoprolol(observation group). Both groups had been treated for 8 weeks. Serum myocardium enzymes, inflammatory factors, heart rate variability indicators, premature beat improvement were recorded before and after treatment and efficacy was compared between the two groups. Results:After treatment, compared with the control group, the levels of serum creatine kinase (CK), lactate dehydrogenase(LDH), creatine kinase-MB(CK-MB), alanine aminotransferase (ALT), aspartic transaminase(AST), C-reactiveprotein(CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) had significantly decreased (all P<0.05), heart rate variability indicators SDNN, SDNNI, SDANN, RMSSD and PNN50 had significantly increased(all P<0.05) in the observation group. There was no deaths in the two groups. The cases of improvement of premature beats and total effective patients in the observation group were more than those in the control group (P<0.05). There was no significant difference of side effectes between the two groups (P>0.05). Conclusion:Metoprolol is effective in the treatment of child arrhythmia, which is related to decreasing of serum myocardial enzymes and inflammatory factors. |