目的：探讨萘哌地尔与曲司氯铵联合应用治疗伴有膀胱过度活动（OAB）样症状远端输尿管结石患者的疗效。方法：选取2014年9月至2016年11月间共119例远端输尿管结石患者作为研究对象，将其随机分为3组，A组38例患者服用萘哌地尔25 mg，1次·d^-1，加用曲司氯铵安慰剂20 mg，2次·d^-1；B组42例患者服用萘哌地尔25 mg，1次·d^-1，加用曲司氯铵20 mg，2次·d^-1；C组39例患者服用曲司氯铵20 mg，2次·d^-1。所有患者随访2周，记录排石率及排石时间。应用改良的OABSS评价患者治疗前、治疗后3 d和7 d的OAB样症状；在治疗2周时以Freiburg患者满意度评分表评价患者治疗满意度。结果：所有患者顺利完成本研究，3组患者的排石率分别为84.2%（32/38）、83.3%（35/42）、59.0%（22/39），C组与A、B两组间差异均有统计学意义（P=0.013）。3组平均排石天数分别为（7.88±2.15）、（8.03±1.99）和（10.13±2.18）d，C组与A、B两组的排石天数差异有统计学意义（P<0.001）。3组间治疗后改良OABSS评分、Freiburg患者满意度评分差异有统计学意义（P<0.001）。结论：萘哌地尔与曲司氯铵联合应用可以缩短远端输尿管结石的排石时间，改善患者OAB样症状，用以治疗远端输尿管结石安全、有效。

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