LOX-1和Vaspin在冠心病患者体内的表达及其与PCI术后再狭窄的关系-东南大学学报医学版

LOX-1和Vaspin在冠心病患者体内的表达及其与PCI术后再狭窄的关系

单位：华北理工大学附属医院心内科, 河北唐山 063000

关键词：血凝素氧化低密度脂蛋白受体-1 内脏脂肪特异性丝氨酸蛋白酶抑制剂经皮冠状动脉介入治疗冠心病再狭窄

分类号：R543.3

出版年·卷·期（页码）：2018·37·第五期（882-886）

摘要：

目的：探讨血凝素氧化低密度脂蛋白受体-1（LOX-1）和内脏脂肪特异性丝氨酸蛋白酶抑制剂（Vaspin）在冠心病患者体内的表达及其与经皮冠状动脉介入（PCI）术后再狭窄的相关性。方法：回顾性分析2013年10月至2016年7月185例在我院行PCI术患者的临床资料，其中男125例，女60例，年龄29~78岁，平均（60.35±10.04）岁。根据其术后再狭窄情况分为非狭窄组（129例）与再狭窄组（56例）。收集患者性别、年龄、高血压、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、糖尿病以及吸烟方面的资料。冠状动脉病变狭窄严重程度采用Gensini积分进行评价。用酶联免疫法测定患者体内LOX-1和Vaspin水平，并分析LOX-1和Vaspin水平与PCI术后再狭窄的关系。结果：与非狭窄组比较，再狭窄组中高LDL-C、低HDL-C以及有吸烟史的比例较高，差异有统计学意义（均P<0.05）。再狭窄组LOX-1水平明显高于非狭窄组，Vaspin水平却明显低于非狭窄组（均P<0.05）。再狭窄组LOX-1水平与Gensini积分呈正相关（r=0.316，P=0.003），Vaspin水平与Gensini积分呈负相关（r=-0.284，P=0.007）。LOX-1（OR=1.876，95% CI 1.452~2.345）、Vaspin（OR=1.755，95% CI 1.430~2.486）均为PCI术后再狭窄的独立危险因素。结论：Gensini积分与LOX-1水平呈正相关，与Vaspin水平呈负相关。体内LOX-1和Vaspin水平均为PCI术后再狭窄的独立危险因素，应予以重视。

Objective:To study the relationship of LOX-1 and Vaspin with restenosis after PCI in patients with coronary artery disease. Methods:Patients with coronary artery disease were retrospectively analyzed, who were admitted to our hospital between October 2013 and July 2016. They were distributed into 2 groups according to the results of restenosis after PCI, including 129 cases of non-restenosis after PCI and 56 cases of restenosis after PCI. Basic situations of the gender, hypertension, high cholesterol, diabetes, and smoking in each patients were analyzed. The severity of coronary artery stenosis was assessed using Gensini integral. The levels of LOX-1 and vaspin in the patients were measured by enzyme-linked immunosorbent assay, and the relationship between LOX-1 and serum vaspin levels and restenosis after PCI was investigated. Results:The proportion of high LDL-C, low HDL-C and smoking history was higher in the restenosis group compared with the non-stenosis group (all P<0.05). The level of LOX-1 in restenosis group was significantly higher than that in non-stenosis group, while the level of Vaspin in restenosis group was significantly lower than that in non-stenosis group (all P<0.05). LOX-1 level was positively correlated with Gensini score (r=0.316,P=0.003) in restenosis group, Vaspin level was negatively correlated with Gensini score(r=-0.284, P=0.007). LOX-1 (OR=1.876,95%CI 1.452-2.345) and Vaspin (OR=1.755,95%CI 1.430-2.486) were independent risk factors for restenosis after PCI. Conclusion:Gensini score is positively correlated with LOX-1 and negatively correlated with Vaspin. In vivo LOX-1 and Vaspin levels are independent risk factors for restenosis after PCI.

参考文献：

[1] RUS.Features of dietary treatment in patients with coronary heart disease[J].Vopr Pitan,2015,84(4):25-36.
[2] DU J,ZHANG D,YIN Y,et al.The Personality and Psychological Stress Predict Major Adverse Cardiovascular Events in Patients with Coronary Heart Disease After Percutaneous Coronary Intervention for Five Years[J].Medicine (Baltimore),2016,95(15):e3364-e3368.
[3] 孙雨华,耿晓坤,张正海,等.分期介入治疗颈动脉狭窄合并冠心病患者的疗效及随访效果观察[J].检验医学与临床,2017,14(9):1257-1259.
[4] 李云,李华,胡劼.超声四维应变成像技术预测冠心病患者PCI术后左室心肌功能改善的研究[J].东南大学学报(医学版),2017,36(5):710-716.
[5] 侯建同,鄢高亮,刘波,等.降钙素原对急性冠状动脉综合征患者行冠状动脉介入治疗后发生造影剂肾病的影响[J].东南大学学报(医学版),2017,36(3):343-347.
[6] HAMEED S,AKHTAR B,AHMAD T,et al.Coronary artery disease and obstructive aortic disease in situs inversus[J].J Coll Physicians Surg Pak,2005,15(12):813-815.
[7] BULLOCK-PALMER R P.Prevention,detection and management of coronary artery disease in minority females[J].Ethn Dis,2015,25(4):499-506.
[8] 王苏梦,张明威,宋令雄,等.急性冠状动脉综合征相关炎性因子的临床价值[J].检验医学与临床,2017,14(14):2025-2027.
[9] HWANG D,LEE J M,KOO B K.Physiologic assessment of coronary artery disease:focus on fractional flow reserve[J].Korean J Radiol,2016,17(3):307-320.
[10] ALRAIES M C,DARMOCH F,TUMMALA R,et al.Diagnosis and management challenges of in-stent restenosis in coronary arteries[J].World J Cardiol,2017,9(8):640-651.
[11] 曹莉,边云飞.替格瑞洛对PCI术后急性冠脉综合征患者血尿酸影响及其抗炎效应[J].中国医院药学杂志,2017,37(15):1498-1501.
[12] 刘波,郭莉,程波,等.曲美他嗪联合运动疗法对冠心病经皮冠状动脉介入术后患者心脏康复的影响[J].中国医院药学杂志,2017,37(4):376-379.
[13] AKHMEDOV A,CAMICI G G,REINER M F,et al.Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels:role of the Oct-1/SIRT1 and ERK1/2 pathways[J].Cardiovasc Res,2017,113(5):498-507.
[14] 苏琳,苗懿德,闫征,等.血凝素样氧化型低密度脂蛋白1基因多态性与汉族老年患者冠状动脉病变的关系[J].中华老年心脑血管病杂志,2011,13(4):316-319.
[15] 景强强,姚龙.冠心病患者PCI围手术期双倍剂量阿托伐他汀干预的效果及安全性分析[J].中南医学科学杂志,2016,44(5):544-547.
[16] STAN ÍK M,SÁGOVÁ I,KANTOROVÁ E,et al.The role of vaspin as a predictor of coronary angiography result in SCAD (stable coronary artery disease) patients[J].BMC Cardiovasc Disord,2017,17(1):117-118.
[17] 肖平喜,谭明娟,万芳,等.血清缺血修饰白蛋白在冠心病患者中的临床应用价值[J].标记免疫分析与临床,2017,24(4):374-377.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录