Objective:To study the relationship of LOX-1 and Vaspin with restenosis after PCI in patients with coronary artery disease. Methods:Patients with coronary artery disease were retrospectively analyzed, who were admitted to our hospital between October 2013 and July 2016. They were distributed into 2 groups according to the results of restenosis after PCI, including 129 cases of non-restenosis after PCI and 56 cases of restenosis after PCI. Basic situations of the gender, hypertension, high cholesterol, diabetes, and smoking in each patients were analyzed. The severity of coronary artery stenosis was assessed using Gensini integral. The levels of LOX-1 and vaspin in the patients were measured by enzyme-linked immunosorbent assay, and the relationship between LOX-1 and serum vaspin levels and restenosis after PCI was investigated. Results:The proportion of high LDL-C, low HDL-C and smoking history was higher in the restenosis group compared with the non-stenosis group (all P<0.05). The level of LOX-1 in restenosis group was significantly higher than that in non-stenosis group, while the level of Vaspin in restenosis group was significantly lower than that in non-stenosis group (all P<0.05). LOX-1 level was positively correlated with Gensini score (r=0.316,P=0.003) in restenosis group, Vaspin level was negatively correlated with Gensini score(r=-0.284, P=0.007). LOX-1 (OR=1.876,95%CI 1.452-2.345) and Vaspin (OR=1.755,95%CI 1.430-2.486) were independent risk factors for restenosis after PCI. Conclusion:Gensini score is positively correlated with LOX-1 and negatively correlated with Vaspin. In vivo LOX-1 and Vaspin levels are independent risk factors for restenosis after PCI.
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