高维持剂量枸橼酸咖啡因对极超低出生体重儿呼吸暂停的临床作用研究-东南大学学报医学版

高维持剂量枸橼酸咖啡因对极超低出生体重儿呼吸暂停的临床作用研究

单位：南京医科大学附属无锡妇幼保健院新生儿科, 江苏无锡 214002

分类号：R722.1

出版年·卷·期（页码）：2018·37·第五期（872-876）

摘要：

目的：探讨不同维持剂量枸橼酸咖啡因对极超低出生体重儿呼吸暂停的临床作用。方法：以2016年1月至2017年11月收治的胎龄25~32周早产儿52例作为研究对象，根据应用枸橼酸咖啡因维持剂量分为低维持剂量给药组和高维持剂量给药组，比较两组患儿临床疗效及并发症。结果：两组间呼吸暂停发生率、撤机成功率、氧疗天数、用药天数、住院天数比较，差异无统计学意义（P>0.05）。两组间脑室内出血（IVH）、坏死性小肠结肠炎（NEC）、早产儿视网膜病（ROP）、支气管肺发育不良（BPD）的发生率比较，差异无统计学意义（P>0.05）。两组间不良反应的发生率比较，差异无统计学意义（P>0.05）。结论：高维持剂量枸橼酸咖啡因没有降低极超低出生体重儿呼吸暂停发生率、氧疗天数、用药天数、住院天数，对临床预后可能无影响。

Objective:To investigate the efficacy of caffeine citrate in very and extremely low birth weight infants at different maintenance doses. Methods:Totally 52 very and extremely low birth weight infants during January 2016 to November 2017 were analyzed. According to the maintenance dosage of caffeine citrate, the patients were divided into the low maintenance dose group and the high maintenance dose group. The clinical efficacy and complications of the two groups were compared. Results:There was no significant difference in the incidence of apnea, the incidence of withdrawal failure, duration of oxygen therapy, intervention duration of caffeine citrate and the time of hospitalization between the two groups (P>0.05). Compared with the low maintenance dose group, the incidences of intraventricular hemorrhage, necrotizing enterocolitis, retinopathy of prematurity and bronchopulmonary dysplasia in the high maintenance dose group were significantly different (P>0.05). There was no significant difference in the untoward effect in two groups (P>0.05). Conclusion:High maintenance dose preventative use of caffeine citrate does not reduce the incidence of apnea and endotracheal intubation, duration of oxygen therapy, intervention duration of caffeine citrate and hospitalization days, and has no effect on clinical prognosis.

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