Objective:To observe the changes of C reactive protein(CRP), soluble myeloid cell triggering receptor -1(sTREM-1) and procalcitonin (PCT) levels in patients with sepsis, and to analyze its clinical significance. Methods:The subjects with sepsis treated in Affiliated Hospital of Nantong University from March 2015 to August 2016 were selected as the subjects, and healthy adults who were examined in our hospital as controls. The levels of CRP, sTREM-1, PCT and APACHE Ⅱ score in the two groups were observed, and the difference of CRP, sTREM-1, PCT levels and APACHE Ⅱ score among patients with different disease degree, different site infection and different prognosis were compared. Results:The levels of CRP, sTREM-1, PCT and APACHE Ⅱ in patients with sepsis were higher than those in the control group (t=59.240, 60.680, 29.603, 34.983, P<0.001); The levels of CRP, sTREM-1, PCT and APACHE Ⅱ in patients with moderate to severe sepsis were higher than those in mild sepsis group (t=-15.216, -8.079, -16.366, -12.072, P<0.001); The levels of CRP, sTREM-1, PCT and APACHE Ⅱ in the patients with lung infection and abdominal infection were higher than those in the bloodstream infection group, but there was no difference between the patients with lung infection and the abdominal infection group; The CRP, sTREM-1, PCT levels and APACHE Ⅱ scores of the patients in the death group were higher than those in the survival group (t=-11.648, -9.807, -7.778, -6.742, P<0.001). Conclusion:The levels of CRP, sTREM-1 and PCT in patients with sepsis are higher than those without sepsis, which are closely related to the severity of the disease and prognosis. |
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