Objective:To investigate the relationship between drug abortion and vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-1 (VEGFR-1) and vascular endothelial growth factor-2 (VEGFR-2). Methods:Ninety cases of complete abortion pregnant women were selected as complete abortion group and 90 cases of incomplete abortion pregnant women were selected as incomplete abortion group from drug abortion pregnant women in our hospital from January 2014 to December 2016.The levels of serum VEGF, VEGFR-1 and VEGFR-2 were measured by ELISA. The expressions of VEGF, VEGFR-1 and VEGFR-2 in villi and decidua were measured by SP immunohistochemistry. Results:Before treatment, there was no significant difference in VEGF, VEGFR-1 and VEGFR-2 between the complete abortion group and the incomplete abortion group (P>0.05). After treatment, the two groups of serum VEGF, VEGFR-1 and VEGFR-2 levels were lower than that before treatment, the incomplete abortion group serum VEGF, VEGFR-1, VEGFR-2, VEGF in chorionic villus and VEGFR-1, VEGFR-2, VEGF, VEGFR-1 in decidua and the positive rate of VEGFR-2 and OD value was higher than that of the complete abortion group, the difference was statistically significant (P<0.05). Conclusion:Compared with those with complete abortion in drug abortion, the expressions of VEGF, VEGFR-1 and VEGFR-2 in serum, villi and decidua tissues are higher than those in women with incomplete abortion. It is concluded that VEGF, VEGFR-1 and VEGFR-2 may be involved in the process of drug abortion. |
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