血清抗苗勒管激素水平检测用于评价宫颈癌患者移位卵巢功能的价值-东南大学学报医学版

血清抗苗勒管激素水平检测用于评价宫颈癌患者移位卵巢功能的价值

单位：南京医科大学附属妇产医院妇产科, 江苏南京 210029

分类号：R737.33

出版年·卷·期（页码）：2018·37·第三期（476-480）

摘要：

目的：通过分析宫颈癌患者卵巢移位术后血清抗苗勒管激素（AMH）水平变化，探讨AMH水平检测用于评价移位卵巢功能的价值。方法：回顾性分析69例宫颈癌患者的临床资料，根据手术前后血清AMH、卵泡刺激素（FSH）水平及改良Kupperman评分值，分析年龄对AMH水平变化的影响，并分析不同手术方式、不同术后治疗方式对AMH水平变化的影响。结果：术前及术后的4次检测中，血清AMH水平随年龄的增长均呈现逐步下降的趋势，较FSH水平及Kupperman评分结果更早出现异常，其中术前、术后6个月、术后12个月下降趋势差异有统计学意义。至术后12个月，除26~30岁组患者与术前相比无明显下降，其他3组较术前均显著降低。行卵巢楔形切除术、术后放化疗者术后AMH水平下降较术前差异有统计学意义。结论：年龄、手术方式及术后辅助放化疗均会影响宫颈癌患者卵巢移位术后卵巢功能，血清AMH水平是评价此类患者卵巢功能的敏感可靠指标。

Objective: To investigate the value of anti-müllerian hormone(AMH) in evaluating ovarian function of cervical cancer patients by analyzing the level of serum AMH after ovarian transposition.Methods: The clinical data of 69 patients with cervical cancer were retrospectively analyzed. AMH level, FSH level and Kupperman score in different periods before and after surgery were analyzed to evaluate the effect of age on AMH level and the influence of different operation methods and chemoradiotherapies on AMH level.Results: With advancing age, AMH level showed the tendency of decline gradually, which was faster than that of FSH and Kupperman score. Before operation, six months after operation and twelve months after operation, the decline was statistically significant. Twelve months after operation,the decline of the 26 to 30 years old group was not significant. The patients receiving ovarian wedge resection and chemoradiotherapy had a more significant decline of AMH level.Conclusion: A significant decrease of AMH level is detected in patients having received ovarian transposition,and AMH level is a sensitive and reliable indicator in evaluating ovarian function of cervical cancer patients.

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