江苏地区5 028例肾活检病理类型与甲状腺疾病关系分析-东南大学学报医学版

江苏地区5 028例肾活检病理类型与甲状腺疾病关系分析

单位：1. 东南大学附属中大医院肾脏病研究所, 江苏南京 210009;
2. 东南大学医学院病理学系, 江苏南京 210009

分类号：R692;R581

出版年·卷·期（页码）：2018·37·第三期（455-458）

摘要：

目的：初步探讨江苏地区5 028例肾活检标本病理类型与甲状腺疾病的关系。方法：回顾性分析东南大学附属中大医院肾脏病研究所行病理诊断的5 028例肾活检标本的临床和病理资料。结果：5 028例肾穿病例中，合并甲状腺疾病者89例，女性占76.41%；甲状腺机能减退在伴发的3种甲状腺疾病中占64%；89例甲状腺疾病与12种肾脏疾病伴发，其中狼疮性肾炎、干燥综合征肾损伤、混合性结缔组织病性肾损伤等自身免疫性疾病伴发率较其他肾脏病为高；甲状腺疾病伴发率在全部肾穿刺标本中或膜性肾病中均有逐年升高趋势。结论：肾穿刺病例中，合并甲状腺疾病以女性、甲状腺机能减退多见；自身免疫性肾脏疾病常伴发甲状腺疾病；肾脏疾病伴发甲状腺疾病逐年增多，应予重视。

Objective: To analyze the relationship between thyroid diseases and pathological patterns in 5 028 cases of renal biopsy in Jiangsu province.Methods: We retrospectively analysed the clinicopathological data of 5 028 cases undergoing percutaneous renal biopsy.Results: In the 5 028 renal patients 89 cases coexisted with thyroid diseases and females accounted for 76.41%. Hypothyroidism accounted for 64% in the three kinds of thyroid diseases. Eighty-nine cases of thyroid disease coexisted with 12 kinds of renal diseases, of which the incidence of coexistence in autoimmunne kidney diseases,such as lupus nephritis,Sjogren syndrome and mixed connective tissue disease, was higher than that of other kidney diseases. There was a yearly increasing tendency of all kidney diseases or membranous nephropathy coexisting with thyroid diseases.Conclusion: The female and hypothyroidism patients of thyroid diseases are commonly found in the renal biopsy. Patients with autoimmune kidney diseases are often complicated with thyroid diseases. It is necessary to pay close attention to the increasing tendency of the coexistence of renal disease and thyroid disease.

参考文献：

[1] 刘婷婷,滕卫平.中国国民碘营养现状与甲状腺疾病[J].中华内科杂志,2017,56(1):62-64.
[2] 滕晓春,滕笛,单忠艳等.碘摄入量增加对甲状腺疾病影响的五年前瞻性流行病学研究[J].中华内分泌代谢杂志,2006,22(6):512-517.
[3] 周岩,程震.甲状腺功能紊乱与慢性肾脏病[J].肾脏病与透析肾移植杂志,2016,25(2):176-180.
[4] DOUSDAMPANIS P,TRIGKA K,VAGENAKIS G A,et al.The thyroid and the kidney:a complex interplay in health and disease[J].Int J Artif Organs,2014,37(1):1-12.
[5] 弓玉祥,陈平圣.1645例肾活检资料的流行病学特点及病理类型分析[J].临床与实验病理学杂志,2014,30(11):1270-1272.
[6] 朱炜琴.11849例健康体检人群甲状腺结节流行病学调查[J].中国疗养医学,2013,22(8):748-749.
[7] 董建华,陈樱花,陈独群,等.狼疮性肾炎合并自身免疫性甲状腺疾病的临床分析[J].肾脏病与透析肾移植杂志,2016,25(6):526-532.
[8] SUNDER S,VENKATARAMANAN K,VERMA H,et al.A rare case of type-Ⅰ auto immune hepatitis and thyroiditis presenting with crescentic glomerulonephritis[J].Saudi J Kidney Dis Transpl,2015,26(5):983-986.
[9] IGLESIAS P,BAJO M A,SELGAS R,et al.Thyroid dysfunction and kidney disease:an update[J].Rev Endocr Metab Disord,2017,18(1):131-144.
[10] PRAJAPATI P,SINGH A P,BENDWAL S.Correlation between severity of chronic kidney disease and thyroid dysfunction[J].J Indian Med Assoc,2013,111(8):514-516.
[11] TULIANI T A,SHENOY M,BELGRAVE K,et al.Role of microalbuminuria in predicting cardiovascular mortality in individuals with subclinical hypothyroidism[J].Am J Med Sci,2017,354(3):285-290.
[12] SANAI T,OKAMURA K,RIKITAKE S,et al.The high prevalence of reversible subclinical hypothyroidism with elevated serum thyroglobulin levels in chronic kidney disease patients[J].Clin Nephrol,2017,87(5):237-244.
[13] CHUANG M H,LIAO K M,HUNG Y M,et al.Association of TSH elevation with all-cause mortality in elderly patients with chronic kidney disease[J].PLoS One,2017,12(1):e0168611.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录