妊娠相关乳腺癌的临床和病理特点及预后的影响因素分析-东南大学学报医学版

妊娠相关乳腺癌的临床和病理特点及预后的影响因素分析

单位：1. 滨州市人民医院乳腺外科, 山东滨州 256600;
2. 滨州市人民医院儿科, 山东滨州 256600

分类号：R737.9

出版年·卷·期（页码）：2018·37·第三期（440-444）

摘要：

目的：研究妊娠相关乳腺癌（PABC）的临床和病理特点及预后的影响因素。方法：以我院收治的90例PABC患者（设为PABC组）及同期收治的90例非PABC患者（设为非PABC组）作为研究对象。回顾性分析患者临床资料，对比分析两组患者的临床和病理特征，并使用Logistic回归分析PABC预后的影响因素。结果：（1）在雌激素受体（ER）阴性率、Ki-67过表达、肿瘤最大直径、腋窝淋巴结转移方面，PABC组与非PABC组之间差异具有统计学意义（P<0.05）；而在孕激素受体（PR）阴性率、人类表皮生长因子受体2（HER-2）表达情况、哺乳史、TNM分期、新辅助化疗、三阴性乳腺癌方面，两组间差异无统计学意义（P>0.05）。（2） PABC组3年生存率和无病生存率明显低于非PABC组（P<0.05）。（3） ER阴性率、Ki-67过表达、肿瘤最大直径、淋巴结转移是影响PABC预后的独立因素。结论：PABC患者早期进行产前检查，选择合适方法加强哺乳期乳腺的检查，密切随访，对提高患者生存率具有重要意义。

Objective: To study the clinical and pathological characteristics of pregnancy-associated breast cancers(PABC) and their prognostic factors.Methods: Ninety patients with PABC treated in our hospital were served as PABC group while 90 cases without PABC were enrolled in non-PABC group. Their clinical data were analyzed retrospectively. The clinical and pathological characteristics of the patients in the two groups were compared and analyzed by Logistic regression analysis.Results: (1)There were significant differences between PABC group and non-PABC group(P<0.05) in ER negative rate, overexpression of Ki-67, the maximum diameter of tumor and axillary lymph node metastasis, while there were no significant differences between the two groups in negative rate of PR, HER-2 receptor, breastfeeding history, TNM staging, neoadjuvant chemotherapy and triple-negative breast cancer(P>0.05). (2)Three-year survival rate and disease-free survival rate were higher in PABC group compared with those in non-PABC group(P<0.05). (3) The negative rate of ER, overexpression of Ki-67, the maximum diameter of tumor and lymph node metastasis were independent prognostic factors of PABC.Conclusion: Patients with PABC should be taken prenatal examination at early stage, and suitable approach should be selected to strengthen breast examination and follow up closely, which is of great significance in improving the survival rate.

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