Objective: To compare analgesic effect of different doses of ropivacaine and its influence on hemodynamic stability for spinal-epidural anesthesia for advanced maternal age.Methods: Ninety cases of advanced maternal age undergoing cesarean section in our hospital were selected as research subjects, and were divided into low dose group and high dose group with 45 cases in each group according to random number table. The low and high dose group were given 0.5% ropivacaine for spinal-epidural anesthesia 2.0 ml and 2.5 ml, respectively, and the analgesic effect, anesthetic effect, hemodynamic indexes and adverse reactions of the two groups before and after medication were compared.Results: VAS score of high dose group was lower than that of low dose group(P<0.05); there was no significant difference in the score of onset time of anesthesia, anesthesia duration and anesthesia block effect between the two groups(P>0.05). Before medication, the blood oxygen saturation, the mean arterial pressure and heart rate of the two groups had no difference(P>0.05). 20 min after medication there was no change in the maternal blood oxygen saturation and mean arterial pressure of low dose group(P>0.05)and the heart rate rose(P<0.05), while the blood oxygen saturation and the mean arterial pressure of high dose group decreased(P>0.05)and the heart rate increased(P<0.05). Difference of blood oxygen saturation, the mean arterial pressure and heart rate of the two groups was statistically significant(P<0.05). The adverse reaction rate(4.4%) of the low dose group was lower than 22.2% of the high dose group, the difference being statistically significant(P<0.05).Conclusion: Low-dose ropivacaine for spinal-epidural anesthesia should be conducted for those of advanced maternal age in cesarean section. Although the analgesic effect is weaker than that of high dose, it has better hemodynamic stability with less adverse reactions, which is worth clinical application.