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活性氧簇对干细胞更新和分化影响的研究进展
作者:曹义娟1  徐惠1  权斌2  胡方方1  刘小燕1  杨亚茹1 
单位:1. 东南大学医学院附属徐州医院/徐州市中心医院 生殖医学中心, 江苏 徐州 221009;
2. 东南大学医学院附属徐州医院/徐州市中心医院 胃肠外科, 江苏 徐州 221009
关键词:活性氧簇 氧化应激 干细胞 肿瘤 综述 
分类号:R73-3
出版年·卷·期(页码):2018·37·第二期(355-359)
摘要:

活性氧簇(ROS)是从分子氧衍化而来的活性成分,干细胞为组织工程、药物筛选、疾病模型的重要研究工具,生理水平ROS是干细胞第二信使,对干细胞增殖、分化和生存必不可少。需氧生物通过非毒性范围内ROS产生和清除的平衡系统调节ROS含量,一旦平衡被打破,细胞将经受氧化应激而造成细胞不可逆的损伤和被杀死,可引起许多疾病。肿瘤干细胞与非肿瘤干细胞相比,产生较少ROS。肿瘤细胞比正常细胞对ROS积聚更为敏感,因此推测外源性ROS可能是肿瘤治疗的有效途径。本综述详细描述了ROS对干细胞自我更新、分化的影响,介绍干细胞内ROS量的调控及其临床应用。

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