[1] KUMARSWAMY R,VOLKMANN I,THUM T.Regulation and function of miRNA-21 in health and disease[J].RNA Biol,2011,8(5):706-713.
[2] SZABO' Z,SZEGEDI K,GOMBOS K,et al.Expression of miRNA-21 and miRNA-221 in clear cell renal cell carcinoma(ccRCC)and their possible role in the development of ccRCC[J].Urol Oncol,2016,34(12):533.e21-533.e27.
[3] JACA A,GOVENDER P,LOCKETZ M,et al.the role of miRNA-21 and epithelial mesenchymal transition(EMT)process in colorectal cancer[J].J Clin Pathol,2017,70(4):331-356.
[4] MARKOU A,ZAVRIDOU M,LIANIDOU E S,et al.miRNA-21 as a novel therapeutic target in lung cancer[J].Lung Cancer(Auckl),2016,7:19-27.
[5] FANG H,XIE J P,ZHANG M,et al.miRNA-21 promotes proliferation and invasion of triple-negative breast cancer cells through targeting PTEN[J].Am J Transl Res,2017,9(3):953-961.
[6] SHAH S,JADHAV K,SHAH V,et al.miRNA 21:diagnostic prognostic and therapeutic marker for oral cancer[J].Microrna,2016,5(3):175-179.
[7] QU K,ZHANG X,LIN T,et al.Circulating miRNA-21-5p as a diagnostic biomarker for pancreatic cancer:evidence from comprehensive miRNA expression profiling analysis and clinical validation[J].Sci Rep,2017,7(1):1692.
[8] NING Q,JIANG X Y.Angiotensin Ⅱ upregulated the expression of microRNA-224 but not microRNA-21 in adult rat cardiac fibroblasts[J].Biomed Rep,2013,1(5):776-780.
[9] TU Y F,WAN L,FAN Y,et al.miRNA-21 protects against cardiac ischemia/reperfusion injury via PTEN/Akt pathway[J].PLoS One,2013,8(10):e75872.
[10] LIU F,YIN L,ZHANG L,et al.Trimetazidine improves right ventricular function by increasing miR-21 expression[J].Int J Mol Med,2012,30(4):849-855.
[11] ROY S,KHANNA S,HUSSAIN S R,et al.MicroRNA expression in response to murine myocardial infarction:MiR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue[J].Cardiovasc Res,2009,82:21-29.
[12] THUM T,GROSS C,FIEDLER J,et al.MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts[J].Nature,2008,456:980-984.
[13] KIM E K,CHOI E J.Pathological roles of MAPK signaling pathways in human diseases[J].Biochim Biophys Acta,2010,1802:396-405.
[14] NISHI H,SAKAGUCHI T,MIYAGAWA S,et al.Impact of microRNA expression in human atrial tissue in patients with atrial fibrillation undergoing cardiac surgery[J].PLoS One,2013,8(9):e73397.
[15] 杨寿娟,张颖,刘寅.冠心病患者外周血中miRNA-21的表达水平及其临床意义[J].中国应用生理学杂志,2015,31(2):127-131.
[16] ZHOU Q,SUN Q,ZHANG Y,et al.Up-regulation of miRNA-21 expression promotes migration and proliferation of Sca-1+ cardiac stem cells in mice[J].Med Sci Monit,2016,23(22):1724-1732.
[17] BAO H,HU S,ZHANG C,et al.Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy[J].Biochem Biophys Res Commun,2014,444(4):455-460.
[18] LU X,FAN Q,XU L,et al.Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression[J].PLoS One,2015,10(2):e0117400.
[19] ZHOU Y,XIONG M,FANG L,et al.miR-21-containing microvesicles from injured tubular epithelial cells promote tubular phenotype transition by targeting PTEN protein[J].J Pathol,2013,183(4):1183-1196.
[20] 马龙,吴昆,刘坤,等.miRNA表达谱在大鼠肾缺血再灌损伤过程中的变化[J].中华医学杂志,2015,95(19):1488-1492.
[21] 钟瑜,韩文伦,朱芸芸,等.纤维化肾小管上皮细胞miRNA-21表达情况研究[J].中国生化药物杂志,2017,37(3):44-47.
[22] YU Z,ZAI C,LUN X W et al.BMP-7 attenuates TGF-β1-induced fibronectin secretion and apoptosis of NRK-52E cells by the suppression of miRNA-21[J].Oncol Res,2016,23(4):147-154.
[23] 陈国萍,李家宁,丛莹莹.N-乙酰半胱氨酸对肺纤维化大鼠Bcl-2/Bax的影响[J].现代医学,2012,40(4):383-389.
[24] XIE T,LIANG J,GUO R,et al.Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation[J].Physiol Genomics,2011,43(9):479-487.
[25] 王晓飞,蔡后荣.特发性肺纤维化相关微小RNA研究进展[J].中华结核和呼吸杂志,2012,35(6):442-446.
[26] CHEN X,BA Y,MA L J et al.Characterization of microRNAs in serum:a novel class of biomarkers for diagnosis of cancer and other diseases[J].Cell Research,2008,18:997-1006.
[27] CHENG F,ZHU D X,HUA J D,et al.Serum microRNAs are promising novel biomarkers for diffuse large B cell lymphoma[J].Ann Hematol,2012,91:553-559.
[28] LIU M W,LIU R,HAI Y,et al.Radix puerariae extracts ameliorate paraquat-induced pulmonary fibrosis by attenuating follistatin-like 1 and nuclear factor erythroid 2p45-related factor-2 signalling pathways through downregulation of miRNA-21 expression[J].BMC Complement Altern Med,2016,16:11.
[29] VETTORI S,GAY S,DISTLER O.Role of MicroRNAs in fibrosis[J].Open Rheumatol J,2012,6(Suppl 1:M9):130-139.
[30] PANDIT K V,CORCORAN D,YOUSEF H,et al.Inhibition and role of let-7d in idiopathic pulmonary fibrosis[J].Am J Respir Crit Care Med,2010,182:220-229.
[31] LIU G,FRIGGERI A,YANG Y,et al.miRNA-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis[J].J Exp Med,2010,207:1589-1597.
[32] LI P,ZHAO G Q,CHEN T F,et al.Serum miR-21 and miR-155 expression in idiopathic pulmonary fibrosis[J].J Asthma,2013,50(9):960-964.
[33] PANDIT K V,MILOSEVIC J,KAMINSKI N.microRNAs in idiopathic pulmonary fibrosis[J].Transl Res,2011,157(4):191-199.
[34] ZHAO J,TANG N,WU K,et al.MiR-21 simultaneously regulates ERK1 signaling in HSC activation and hepatocyte EMT in hepatic fibrosis[J].PLoS One,2014,9(10):e108005.
[35] HE X,XIE J,ZHANG D,et al.rAAV8-mediated inhibition of miRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and TGF-β1 pathways[J].Hepatology,2015,61(6):2008-2017.
[36] TONG B D,XIAO M Y,ZENG J X,et al.MiRNA-21 promotes fibrosis in orbital fibroblasts from thyroid-associated ophthalmopathy[J].Mol Vis,2015,21:324-334.
[37] KOR K,TURNER A P,ZAREI K,et al.Structurally responsive oligonucleotide-based single-probe lateral-flow test for detection of miRNA-21 mimics[J].Anal Bioanal Chem,2016,408(5):1475-1485.
[38] ZHU Y,QIU D,YANG G,et al.Selective and sensitive detection of miRNA-21 based on gold-nanorod functionalized polydiacetylene microtube waveguide[J].Biosens Bioelectron,2016,85:198-204.
[39] MIAO X,WANG W,KANG T,et al.Ultrasensitive electrochemical detection of miRNA-21 by using an iridium(Ⅲ)complex as catalyst[J].Biosens Bioelectron,2016,86:454-458.
[40] FANG C S,KIM KS,YU B,et al.miRNA ultrasensitive electrochemical detection of miRNA-21 using a Zinc finger protein specific to DNA-RNA hybrids[J].Anal Chem,2017,89(3):2024-2031.
[41] RAFIEE P H A,BEHPOUR M,KESHAVARZ M.A novel label-free electrochemical miRNA biosensor using methylene blue as redox indicator:application to breast cancer biomarker miRNA-21[J].Biosens Bioelectron,2016,77:202-207.
[42] YAN H,BHATTARAI U,GUO Z F,et al.Regulating miRNA-21 biogenesis by bifunctional small molecules[J].J Am Chem Soc,2017,29.doi:10.1021/jacs.7b00610. |
