Objective:To evaluate the clinical efficacy and prognosis of endoscopic variceal ligation (EVL) and endoscopic injection sclerotherapy (EIS) on esophageal varices. Methods:It was a retrospective study of 126 patients with hepatic cirrhosis and esophageal varices undergoing EVL and EIS, respectively. The characteristics and prognosis of the EVL group and the EIS group were compared to evaluate two interventions. Results:There was no difference between the EVL group and the EIS group at baseline. In 2 weeks after the intervention, three participants reported complications in the EVL group, while nine in the EIS group. In 6 weeks after the intervention, two patients presented re-bleeding in the EVL group, whereas six in the EIS group, but there were no differences of complications and re-bleeding (P>0.05). A follow-up of 6 months presented a recurrence rate of 66.67% (28/42) in the EVL group, while it was 38.10% (32/84) in the EIS group (P<0.05). After a 12-month follow-up, the recurrence rate in the EVL group was 83.33% (35/42), while it was 51.19% (43/84) in the EIS group (P<0.05).Conclusion:EVL and EIS both presented acceptable results in the clinical administration on esophageal varices.There are no significant differences in complications and re-bleeding rate during the early phase. However,but the recurrence rate of varicose veins in EIS group is significantly lower than that in the EVL group.