Objective: To observe and study the the correlation between low density lipoprotein cholesterin(LDL-C) and cerebral small vascular disease(CSVD), and study the influence of CSVD on the cognition of patients. Methods: 246 patients(151 males and 95 females are included, and average age was(52.1±14.7) years old), who have ever visited the people's hospital of Dongying district from September 2012 to September 2015, were selected and divided into 3 groups according to the MRI examination: White Matter Lesions(WML) group(86 patients), Lacunar Infarction(LI) group(53 patients) and control group(107 patients). MMSE test and Montreal cognitive score(MoCA) were evaluated among the cases.The results was recorded and analyzed.Results: Compared with the control group, patients in the LI and WML group have a significantly difference on the factors LDL-C, TG and TC. No difference between the LI and WML group. No significant difference of other factors was found between the 3 groups(P > 0.05). The MMSE and MoCA averaged score in the LI and WML group were significantly lower than that of the control group(P<0.05), but no significant difference between LI and WML group(P > 0.05). When the various risk factors were considered as independent variables, LI or WML was taken as dependent variable, it was found that the coincidence of LI and WML were related with the level of low density lipoprotein cholesterol in Logistic regression analysis and matching data correlation analysis. Conclusion: LDL-C is an important risk factor of CSVD. In patients with hyperlipidemia, the understanding and alert of CSVD should be improved.When conditions allow, cerebral MRI or CT examination is recommended to rule out the existence of CSVD.By lowering the level of low-density lipoprotein cholesterol(LDL-C), improving endothelial function, anti-inflammatory and neural protection measures,we expect to intervene CSVD earlier and reduce clinical adverse events. |
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