首发青少年重性抑郁障碍患者静息态脑磁频谱功率研究-东南大学学报医学版

首发青少年重性抑郁障碍患者静息态脑磁频谱功率研究

单位：1. 广州中医药大学经管学院, 广东广州 510006;
2. 广东三九脑科医院心理行为科, 广东广州 510510;
3. 广东三九脑科医院影像科, 广东广州 510510

分类号：R749.4

出版年·卷·期（页码）：2018·37·第一期（64-68）

摘要：

目的：分析首发青少年重性抑郁障碍患者静息态脑磁频谱功率分布特征及额叶alpha波偏侧化特点，探究抑郁障碍发生的电生理学机制，为脑磁图技术在抑郁障碍的临床应用方面提供参考。方法：选取2016年10月至2017年6月于广东三九脑科医院精神科就诊的首次发病青少年（13~19岁）重性抑郁障碍患者列为病例组研究对象，并招募健康志愿者10名列为对照组；运用148通道全头型脑磁图系统采集两组静息态脑磁图信号，计算脑磁图各频道不同区域（左右两侧的中央区、额叶、颞叶、顶叶、枕叶）频谱功率，并进行分析。结果：与健康对照组相比，首发青少年重性抑郁障碍患者病例组左侧顶叶delta波频谱功率增强（P < 0.05），右侧颞叶和右侧枕叶theta波频谱功率增强（P < 0.01）；男性患者比女性患者顶叶delta波频谱功率增强（P < 0.05）；额叶alpha波未发现显著的偏侧化特点（P>0.05）。结论：首发青少年重性抑郁障碍患者存在多个频段皮层激活异常，脑磁频谱慢波功率异常可能与青少年抑郁障碍发病相关。

Objective: To analyze the characteristics of the magnetoencephalography (MEG) and frontal asymmetry in alpha oscillations of teenagers with first-episode major depressive disorder,to explore the electrophysiological mechanism of the occurrence of depressive disorder,and to provide reference for the clinical application of MEG. Methods: Selected the adolescents (13-19 years old) patients with first-episode major depressive disorder from October 2016 to June 2017 in Guangdong 999 brain hospital,and recruited 10 healthy volunteers as a control group.Scanned magnetic fields signals in the brain (Left and right sides of the central area,frontal lobe,temporal lobe,parietal lobe and occipital lobe) from the two groups using the 148-channel MEG system.Calculated and analyzed the spectral power. Results: Compared with the control group,the power of delta band in the left parietal lobe was increased (P<0.05) in the patient groups.The power of theta band in the right temporal lobe and parietal lobe are both increased (P<0.01) in the patient groups.For male patients,the power of delta band in the left parietal lobe was increased more than female patients (P<0.05).Frontal asymmetry in alpha oscillations was not to be proved on MEG (P>0.05). Conclusion: The present study suggests that teenagers with first-episode major depressive disorder have impaired neural activity at many bands,the changes of the power of delta and theta bands might be relevant to teenagers major depressive disorder.

参考文献：

[1] 朱旌,汪璐.世卫组织报告:全球抑郁症发病率上升引人担忧[EB/OL],2017-02-05.
[2] 陶然,纪文博,张惠敏,等.青少年抑郁症研究新进展[J].武警医学2015,26(2):109-111.
[3] 汤浩.抑郁症静息脑磁频谱分布及功能连接特征的初步探讨[D].南京:南京医科大学,2013.
[4] ALAMIAN G,HINCAPIÉ A S,COMBRISSON E,et al.Alterations of intrinsic brain connectivity patterns in depression and bipolar disorders:A critical assessment of magnetoencephalography-based evidence.[J].Front Psychiatry,2017,8(3):41.
[5] 孙长安,蔡厚德,葛爱荣.强迫症患者的脑电图与强迫症状的相关研究[J].中华行为医学与脑科学杂志,2010(2):157-158.
[6] GRIN-YATSENKO V A,BAAS I,PONOMAREV V A,et al.Independent component approach to the analysis of EEG recordings at early stages of depressive disorders[J].Clin Neurophysiol,2010,121(3):281-289.
[7] FINGELKURTS A A,FINGELKURTS A A,RYTSÄLÄ H,et al.Composition of brain oscillations in ongoing EEG during major depression disorder[J].Neurosci Res,2006,56(2):133-144.
[8] 闫伟,谢世平,王沛弟.抑郁症的脑磁图研究进展[J].临床精神医学杂志,2009,19(5):348-350.
[9] BASAR E,GVNTEKIN B.A short review of alpha activity in cognitive processes and in cognitive impairment.Int J Psychophysiol,2012,86(1):25-38.
[10] SINGH Y,SINGH J,SHARMA R,et al.FFT transformed quantitative EEG analysis of short term memory load[J].Ann Neurosci,2015,22(3):176-179.
[11] 贾凤南,汤浩,史家波,等.双相抑郁患者特定临床症状与脑磁图特征[J].中国神经精神疾病杂志,2015,41(8):477-481.
[12] 郭云霞,艾司西酞普兰与帕罗西汀治疗女性抑郁症对照研究[J].新乡医学院学报,2017,34(07):644-646.
[13] 冯朝霞.中学生学习方式的调查研究[D].上海:华东师范大学,2015.
[14] 喻爱军,王挺,黄胜等.黎族大学生积极/消极情感的性别差异[J].中国健康心理学杂志,2013,21(9):1399-1341.
[15] JETHA M K,SCHMIDT L A,GOLDBERG J O.Long-term stability of resting frontal EEG alpha asymmetry and power in a sample of stable community outpatients with schizophrenia[J].Int J Psychophysiol,2009,72(2):228-233.
[16] KEMP A H,GRIFFITHS K,FELGHAM K L,et al.Disorder specificity despite comorbidity:Resting EEG alpha asymmetry in major depressive disorder and post-traumatic stress disorder[J].Biol Psychiatry,2010,85(2):350-354.
[17] ZOTEV V,YUAN H,MISAKI M,et al.Correlation between amygdala BOLD activity and frontal EEG asymmetry during real-time fMRI neurofeedback training in patients with depression[J].Neuroimage Clin,2016(11):224-238.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录