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Cav-1在肝癌组织的表达及其意义
作者:刘振华1  李小宁1  陈平圣2 
单位:1. 苏州卫生职业技术学院 病理学教研室, 江苏 苏州 215009;
2. 东南大学医学院 病理学系, 江苏 南京 210009
关键词:肝癌 Cav-1 组织微阵列 免疫组织化学 
分类号:R361.2
出版年·卷·期(页码):2018·37·第一期(35-40)
摘要:

目的:探讨小窝蛋白-1(Cav-1)在肝癌(HCC)细胞及间质中的表达及意义。方法:采用组织微阵列及免疫组织化学法检测100例肝癌及癌旁组织Cav-1的表达,并分析其表达程度与病理参数的相关性。结果:Cav-1在肝癌细胞的高表达率显著高于癌旁组织(P<0.05);而且与微血管的侵袭、癌栓的形成、周围脏器的直接侵袭、是否伴有肝硬化显著正相关。Cav-1在肝癌间质的高表达率显著低于癌旁间质(P<0.05),而且与肿瘤的大小、卫星结节的形成、微血管的侵犯、癌栓的形成、周围脏器的直接侵袭显著正相关。结论:在肝癌组织中,Cav-1的高表达率在肝癌细胞上调,而在肝癌间质下调;Cav-1在肝癌细胞及肝癌间质的表达变化与肝癌的侵袭性有关。

Objective: To investigate the expression of Caveolin-1 in HCC and its connotation. Methods: Using tissue microarray and immune histochemical method to detect the expression of Cav-1 in 100 cases HCC and tissue adjacent to carcinoma and analyze the correlation of the expression and the pathological parameters. Results: The high expression rate of Cav-1 in HCC was significantly higher than that in the adjacent tissues(P<0.05); and was significantly positively related with microvascular invasion, the formation of tumor emboli, direct invasion of adjacent organs and liver cirrhosis. The high expression rate of Cav-1 in HCC mesenchyme was significantly lower than that in the adjacent liver mesenchyme(P<0.05), and was significantly positively related with the tumor size, satellite nodules, microvascular invasion, the formation of tumor emboli, and direct invasion of adjacent organs. Conclusion: The expression of Cav-1 in HCC cells was increased, and was decreased in the HCC mesenchyme, the changes of the expression of Cav-1 in HCC cells and mesenchymal was associated with the invasive ability of HCC.

参考文献:

[1] RAMPONE B,SCHIAVONE B,CONFUORTO G.Current management of hepatocellular cancer[J].Curr Oncol Rep,2010,12(3):186-192.
[2] 董伟家,张建国,杨景武,等.Caveolin-1在肿瘤中的表达及临床意义[J].基础医学与临床,2008,28(10):1111-1116.
[3] ZHENG J.Energy metabolism of cancer:glycolysis versus oxidative phosphorylation(Review)[J].Oncol Lett,2012,4(6):1151-1157.
[4] PAVLIDES S,VERA I,GANDARA R,et al.Warburg meets autophagy:cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress,mitophagy,and aerobic glycolysis[J].Antioxid Redox Sign,2012,16(11):1264-1284.
[5] BONUCCELLI G,WHITAKER-MENEZES D,CASTELLO-CROS R,et al.The reverse warburg effect glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblast[J].Cell Cycle,2010,9(10):1960-1971.
[6] 单涛,郑波,陈熹,等.Cav-1在胰腺癌中表达及与临床预后关系的研究[J].东南大学学报:医学版,2015,34(4):552-557.
[7] H YOKOMORI,M ODA,K YOSHIMURA,et al.Elevated expression of caveolin-1 at protein and mRNA level in human cirrhotic liver:relation with nitric oxide[J].J Gastroen Hepatol,2003,38(9):854-860.
[8] ANDERS R A,YERIAN L M,TRETIAKOVA M,et al.cDNA microarray analysis of macroregenerative and dysplastic nodules in end-stage hepatitis C virus-induced cirrhosis.Am J Pathol,2003,162(3):991-1000.
[9] MAO X,WONG S Y,TSE E Y,et al.Mechanisms through which hypoxia-induced caveolin-1 drives tumorigenesis and metastasis in hepatocellular carcinoma[J].Cancer Res,2016,76(24):7242-7253.
[10] LIU W R,JIN L,TIAN M X,et al.Caveolin-1 promotes tumor growth and metastasis via autophagy inhibition in hepatocellular carcinoma[J].Gastroen Clin Biol,2015,53(12):169-178.
[11] COKAKLI M,ERDAL E, NART D,et al.Differential expression of Caveolin-1 in hepatocellular carcinoma:correlation with differentiation state,motility and invasion[J].BMC Cancer,2009,9(1):65.
[12] BURGERMEISTER E,XING X,ROCKEN C,et al.Differential expression and function of caveolin-1 in human gastric cancer progression[J].Cancer Res,2007,67(18):8519-8526.
[13] 潘一明.CAV-1在肝细胞性肝癌中的表达及其与肿瘤血管新生的关系[D].南京,南京大学出版社,2007:21-25.
[14] FANG K,FU W,BEARDSLEY A R,et al.Overexpression of caveolin-1 Inhibits endothelial cell proliferation by arresting the Cell Cycle at G[J].Cell Cycle,2007,6(2):199-204.
[15] 赵朋月,刁路明,陈洪雷.基质窖蛋白-1和肿瘤能量代谢的研究进展[J].中华病理学杂志,2012,41(7):498-500.
[16] PAVLIDES S,WHITAKER-MENEZES D,CASTELLO-CROSR,et al.The reverse warburg effect:aerobic glycolysis in cancer associated fibroblasts and the tumor stroma[J].Cell Cycle,2009,8(23):3984-4001.
[17] 李建华,吕伟鹏,朱瑞萍,等.Caveolin-1在乳腺癌间质中的表达及与预后的关系[J].大连医科大学学报,2017,39(2):132-136.

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