Objective: To study the effect of renal sympathetic denervation(RSD) for spontaneously hypertensive rats(SHR) and the relationship between RSD and expressions of miR-150、miR-155、miR-124、miR-135a and miR-143/145 in aorta artery tissue and peripheral blood. Method: A total of 40 healthy SHR Wistar rats and 40 normal rats(WKY) were divided randomly into operation and sham sub-groups,20 rats in each group: SHR control group, SHR operation group, WKY control group and WKY operation group, SHR control group and WKY control group accepted sham operation, SHR operation group and WKY operation group underwent operation. The miR-150, miR-155, miR-124, miR-135a and miR-143/145 in peripheral blood before and 4, 8, 16 and 24 weeks after operation,the values of systolic(SBP) and diastolic(DBP) blood pressure of rat tail artery;the above miRNAs in aorta artery tissue by RT-PCR after 24 weeks by killed rats. Results: The blood pressure and miRNAs of 4 groups were different at different time (P<0.05). Compared with the SHR control group, the systolic and diastolic blood pressure and miRNAs of SHR operation group were lower (P<0.05). Compared with the WKY control group, the systolic and diastolic blood pressure and miRNAs of WKY operation group were lower (P<0.05). The miRNAs of WKY control group and WKY operation group had no differences(P>0.05). Conclusion: It is effective and stable for RSD in SHR rats by lowerring miR-150, miR-155, miR-124, miR-135a and miR-143/145 in peripheral blood and aorta artery tissue.
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