放射性核素标记多功能纳米系统在恶性肿瘤诊治中的应用-东南大学学报医学版

放射性核素标记多功能纳米系统在恶性肿瘤诊治中的应用

单位：南京中医药大学附属医院核医学科, 江苏南京 210019

分类号：R817

出版年·卷·期（页码）：2017·36·第六期（1044-1048）

摘要：

随着纳米技术和分子影像学的发展，多功能纳米载体系统响应了目前临床医学以及基础医学的需求。白蛋白纳米载体、脂质体纳米载体、磁性材料纳米载体以及碳纳米载体等是目前研究的较多的纳米载体。将放射性核素与多功能纳米载体相结合，利用纳米载体的粒径小、缓释性以及表面可修饰性等特点可将放射性核素本身的治疗效果发挥至最佳。不仅可以减少放射性核素的毒副作用，而且可以提高放射性核素的治疗效率和靶向浓度。以纳米技术为核心，将生物医学治疗和分子影像学相结合的诊断治疗一体化新模式将成为未来临床医学发展的新思路。

With the development of the nanoparticles and molecular imaging, the multifunctional nanoparticles have responded to the needs of current clinical medicine. More and more nanoparticles have used in experimental research such as albumin nanoparticles, liposomes, magnetic materials and carbon nanoparticles. With the combining radionuclide with multifunctional nanoparticles, the nanoparticles have the advantages of small size, slow release and surface modification, so that the therapeutic effect of radionuclides can efficient. Not only it can reduce the toxic and side effects of the radionuclides, but also improve the therapeutic efficiency and target concentration. With nanotechnology as the core, the integration of biomedical treatment and molecular imaging in diagnosis and treatment will become a new way of clinical medicine development in the future.

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