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椎间盘生物学及细胞表型的研究进展
作者:胡义立1  吴小涛2  王锋2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 脊柱外科, 江苏 南京 210009
关键词:椎间盘 脊索 髓核细胞 纤维环细胞 终板软骨细胞 细胞表型 文献综述 
分类号:R681.53
出版年·卷·期(页码):2017·36·第六期(1040-1043)
摘要:

椎间盘退变是腰背痛的主要原因,研究椎间盘发育、退变,结构功能以及椎间盘中各种细胞的特异性标志物有助于椎间盘疾病的治疗。近年来的研究发现,椎间盘起源于脊索,椎间盘退变始于髓核细胞类型和数量的改变,同时也伴随着纤维环细胞和终板软骨细胞的改变。髓核细胞有相对系统的标志物,而纤维环细胞和终板软骨细胞尚无明确的标志物。作者就椎间盘的生物学特征以及椎间盘内各种细胞标志物的研究进展作一综述。

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