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快速抗抑郁药物作用机制的研究进展
作者:王梅蕾1  张志珺2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 神经内科, 江苏 南京 210009
关键词:抑郁症 N-甲基-D-天冬氨酸受体 氯胺酮 文献综述 
分类号:R966
出版年·卷·期(页码):2017·36·第六期(1023-1027)
摘要:

目前用于治疗抑郁症的药物存在有效率低、起效慢、毒副作用大等问题。研究表明,N-甲基-D-天冬氨酸受体(NMDA)拮抗剂氯胺酮在数小时内可产生持续2周的抗抑郁效应,而且对于重度抑郁患者仍然有效。虽然氯胺酮能在短时间内快速起效,但其存在肢体感觉障碍、焦虑、恶心、头晕、血压升高及心率加快等一系列毒副作用,使其在临床上广泛应用受到了限制。因此研究氯胺酮快速抗抑郁的分子机制对于开发与氯胺酮具有类似效应而副作用小的抗抑郁药物有着极大的意义。作者对氯胺酮快速抗抑郁机制的研究进展作一综述。

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