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难治性分化型甲状腺癌的研究进展
作者:黄韬  胡丽丽  周军 
单位:连云港市第一人民医院 甲乳外科, 江苏 连云港 222002
关键词:分化型甲状腺癌 放射性碘治疗 基因突变 靶向治疗 综述 
分类号:R736.1
出版年·卷·期(页码):2017·36·第五期(876-881)
摘要:

甲状腺癌是最常见恶性肿瘤之一,发病率呈逐年上升趋势。分化型甲状腺癌约占全部甲状腺癌的85%以上,主要包括甲状腺乳头状癌(papillary thyroid carcinoma,PTC)与甲状腺滤泡状癌(follicular thyroid carcinoma,FTC)两种病理类型,一般预后较好,但仍有约10%的病例经常规治疗效果不佳,此类病人多对放射性碘治疗不敏感,且有1个或多个癌基因的突变,易发生术后局部复发及远处转移。本文作者综述了难治性分化型甲状腺癌常见的基因变异位点及靶向治疗的最新研究进展。

参考文献:

[1] 伊丹丹,黄韬,宋鹏,等.甲状腺微小乳头状癌手术方式对肿瘤复发影响的meta分析[J].东南大学学报:医学版,2017,36(1):48-52.
[2] DAVIES L,WELCH H G.Current thyroid cancer trends in the United States[J].JAMA Otolaryngol Head Neck Surg,2014,140(4):317-322.
[3] LAWRENCE M S,STOJANOV P,POLAK P,et al.Mutational heterogeneity in cancer and the search for new cancer-associated genes[J].Nature,2013,499(7457):214-218.
[4] Cancer Genome Atlas Research Network.Integrated genomic characterization of papillary thyroid carcinoma[J].Cell,2014,159(3):676-690.
[5] MONTERO-CONDE C,RUIZ-LLORENTE S,DOMINGUEZ J M,et al.Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas[J].Cancer Discov,2013,3(5):520-533.
[6] LITO P,PRATILAS C A,JOSEPH E W,et al.Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas[J].Cancer Cell,2012,22(5):668-682.
[7] POULIKAKOS P I,ZHANG C,BOLLAG G,et al.RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF[J].Nature,2010,464(7287):427-430.
[8] SABRA M M,DOMINGUEZ J M,GREWAL R K,et al.Clinical outcomes and molecular profile of differentiated thyroid cancers with radioiodine-avid distant metastases[J].J Clin Endocrinol Metab,2013,98(5):E829-836.
[9] HO A L,GREWAL R K,LEBOEUF R,et al.Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer[J].N Engl J Med,2013,368(7):623-632.
[10] NIKIFOROV Y E,SEETHALA R R,TALLINI G,et al.Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma:a paradigm shift to reduce overtreatment of indolent tumors[J].JAMA Oncol,2016,2(8):1023-1029.
[11] RABES H M,DEMIDCHIK E P,SIDOROW J D,et al.Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas:biological,phenotypic,and clinical implications[J].Clin Cancer Res,2000,6(3):1093-1103.
[12] GUDMUNDSSON J,SULEM P,GUDBJARTSSON D F,et al.Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations[J].Nat Genet,2009,41(4):460-464.
[13] GARA S K,JIA L,MERINO M J,et al.Germline HABP2 mutation causing familial nonmedullary thyroid cancer[J].N Engl J Med,2015,373(5):448-455.
[14] SAHASRABUDHE R,ESTRADA A,LOTT P,et al.The 8q24 rs6983267G variant is associated with increased thyroid cancer risk[J].Endocr Relat Cancer,2015,22(5):841-849.
[15] TOMSIC J,FULTZ R,LIYANARACHCHI S,et al.HABP2 G534E variant in papillary thyroid carcinoma[J].PLoS One,2016,11(1):e0146315.
[16] SOBRINHO-SIMÖES M,ELOY C,MAGALHÄES J,et al.Follicular thyroid carcinoma[J].Mod Pathol,2011,24(Suppl 2):S10-18.
[17] LANDA I,GANLY I,CHAN T A,et al.Frequent somatic TERT promoter mutations in thyroid cancer:higher prevalence in advanced forms of the disease[J].J Clin Endocrinol Metab,2013,98(9):E1562-1566.
[18] CIBAS E S,ALI S Z.The bethesda system for reporting thyroid cytopathology[J].Am J Clin Pathol,2009,132(5):658-665.
[19] SANTHANAM P,KHTHIR R,GRESS T,et al.Gene expression classifier for the diagnosis of indeterminate thyroid nodules:a meta-analysis[J].Med Oncol,2016,33(2):14.
[20] NIKIFOROV Y E,CARTY S E,CHIOSEA S I,et al.Impact of the multi-gene ThyroSeq next-generation sequencing assay on cancer diagnosis in thyroid nodules with atypia of undetermined significance/follicular lesion of undetermined significance cytology[J].Thyroid,2015,25(11):1217-1223.
[21] HAUGEN B R,ALEXANDER E K,BIBLE K C,et al.2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer:the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer[J].Thyroid,2016,26(1):1-133.
[22] ODA H,MIYAUCHI A,ITO Y,et al.Incidences of unfavorable events in the management of low-risk papillary microcarcinoma of the thyroid by active surveillance versus immediate surgery[J].Thyroid,2016,26(1):150-155.
[23] TUTTLE R M,TALA H,SHAH J,et al.Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation:using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system[J].Thyroid,2010,20(12):1341-1349.
[24] XING M,ALZAHRANI A S,CARSON K A,et al.Association between BRAF V600E mutation and recurrence of papillary thyroid cancer[J].J Clin Oncol,2015,33(1):42-50.
[25] HUANG F W,HODIS E,XU M J,et al.Highly recurrent TERT promoter mutations in human melanoma[J].Science,2013,339(6122):957-959.
[26] XING M,LIU R,LIU X,et al.BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence[J].J Clin Oncol,2014,32(25):2718-2726.
[27] HAY I D,LEE R A,DAVIDGE-PITTS C,et al.Long-term outcome of ultrasound-guided percutaneous ethanol ablation of selected "recurrent" neck nodal metastases in 25 patients with TNM stages Ⅲ or Ⅳ A papillary thyroid carcinoma previously treated by surgery and 131I therapy[J].Surgery,2013,154(6):1448-1454.
[28] TUFANO R P,CLAYMAN G,HELLER K S,et al.Management of recurrent/persistent nodal disease in patients with differentiated thyroid cancer:a critical review of the risks and benefits of surgical intervention versus active surveillance[J].Thyroid,2015,25(1):15-27.
[29] SCHVARTZ C,BONNETAIN F,DABAKUYO S,et al.Impact on overall survival of radioactive iodine in low-risk differentiated thyroid cancer patients[J].J Clin Endocrinol Metab,2012,97(5):1526-1535.
[30] SCHLUMBERGER M,CATARGI B,BORGET I,et al.Strategies of radioiodine ablation in patients with low-risk thyroid cancer[J].N Engl J Med,2012,366(18):1663-1673.
[31] WANG W,LARSON S M,TUTTLE R M,et al.Resistance of[18f]-fluorodeoxyglucoseavid metastatic thyroid cancer lesions to treatment with high-dose radioactive iodine[J].Thyroid,2001,11(12):1169-1175.
[32] ROTHENBERG S M,MCFADDEN D G,PALMER E L,et al.Redifferentiation of iodine-refractory BRAF V600 Emutant metastatic papillary thyroid cancer with dabrafenib[J].Clin Cancer Res,2015,21(5):1028-1035.
[33] ORITA Y,SUGITANI I,TODA K,et al.Zoledronic acid in the treatment of bone metastases from differentiated thyroid carcinoma[J].Thyroid,2011,21(1):31-35.
[34] SCHLUMBERGER M,TAHARA M,WIRTH L J,et al.Lenvatinib versus placebo in radioiodine-refractory thyroid cancer[J].N Engl J Med,2015,372(7):621-630.
[35] BROSE M S,NUTTING C M,JARZAB B,et al.Sorafenib in radioactive iodine-refractory,locally advanced or metastatic differentiated thyroid cancer:a randomised,double-blind,phase 3 trial[J].Lancet,2014,384(9940):319-328.
[36] DUNN L,FAGIN J A.Therapy:lenvatinib and radioiodine-refractory thyroid cancers[J]. Nat Rev Endocrinol,2015,11(6):325-327.
[37] BIBLE K C,SUMAN V J,MOLINA J R,et al.Efficacy of pazopanib in progressive,radioiodine-refractory,metastatic differentiated thyroid cancers:results of a phase 2 consortium study[J].Lancet Oncol,2010,11(10):962-972.
[38] HICK A C,DELMARCELLE A S,BOUQUET M,et al.Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation[J].Dev Biol,2013,381(1):227-240.
[39] JAIN R K.Antiangiogenesis strategies revisited:from starving tumors to alleviating hypoxia[J].Cancer Cell,2014,26(5):605-622.
[40] LANDA I,IBRAHIMPASIC T,BOUCAI L,et al.Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers[J].J Clin Invest,2016,126(3):1052-1066.
[41] CHAPMAN P B,HAUSCHILD A,ROBERT C,et al.Improved survival with vemurafenib in melanoma with BRAF V600E mutation[J].N Engl J Med,2011,364(26):2507-2516.
[42] TIACCI E,PARK J H,de CAROLIS L,et al.Targeting mutant BRAF in relapsed or refractory hairy-cell leukemia[J].N Engl J Med,2015,373(18):1733-1747.
[43] KOPETZ S,DESAI J,CHAN E,et al.Phase Ⅱ pilot study of vemurafenib in patients with metastatic BRAF-mutated colorectal cancer[J] J Clin Oncol,2015,33(34):4032-4038.
[44] BROSE M S,CABANILLAS M E,COHEN E E,et al.Vemurafenib in patients with BRAF(V600E)-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine:a non-randomised,multicentre,open-label,phase 2 trial[J].Lancet Oncol,2016,17(9):1272-1282.
[45] 刘军,苏磊,桑剑锋,等.颈部低位领式切口行甲状腺癌择区性颈清扫的临床应用[J].东南大学学报:医学版,2015,34(4):572-576.

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